SBIR Phase I: Lignin-Based Formulations for Efficient and Sustainable Control of Plant Pathogens

SBIR 第一阶段：基于木质素的制剂，用于有效和可持续地控制植物病原体

• 批准号: 1746692
• 负责人: Anka Veleva
• 金额: $ 22.5万
• 依托单位: BENANOVA Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1746692&HistoricalAwards=false
• 关键词: SBIR; Phase; Lignin; Based; Formulations

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project encompasses the development of a continuous fabrication process to enable production of larger volumes of the next generation of agrochemical compounds. Although the first focus is on utilization for efficient delivery of antimicrobial and antifungal crop protection chemicals, this platform can be applied for actives and biologicals with other functionalities. The broader significance of this research and development effort entails the following aspects: First, in addition to agricultural crop protection products, the delivery system developed here is expected to find commercial applications in many products targeted to the consumer, construction markets, and healthcare. Second, the formulation of benign small structures that have the potential to replace a wide range of persistent and harmful nanoparticles in various industrial settings will enhance scientific and technological understanding of scalable processes on the nanoscale. Third, the sustainable solutions developed in this project could strengthen existing natural resources, enhance biosecurity of the U.S. food supply, and improve public health. This SBIR Phase I project proposes to engineer an innovative system for efficient delivery of agricultural actives. To increase productivity, current agricultural practices utilize large amounts of crop protection chemicals. However, the intensive use of agrochemicals creates environmental threats damaging natural resources and potentially causing climate change. To address these challenges we are developing innovative, breakthrough platform technology with potential to increase efficiency of farming with the same or fewer inputs, while protecting the environment. The goal of this work is to create a new class of scalable, functionally active, sustainable and eco-friendly materials based on the widely available, biodegradable and bio-renewable resource lignin. The first objective of the project is to build a continuous flow process for preparation of lignin particles functionalized with small amounts of active biocides. This research will establish feasibility for continuous formulation of these preparations. The second objective of the study includes characterization of the new formulations using a series of antimicrobial and antifungal assays. As a result of the Phase 1 effort, technical risk will be reduced by identifying the most promising formulations for field studies to be conducted in Phase 2.

该小企业创新研究 (SBIR) 项目的更广泛影响/商业潜力包括开发连续制造工艺，以实现更大量的下一代农化化合物的生产。尽管首要重点是利用抗菌和抗真菌作物保护化学品的高效输送，但该平台可应用于具有其他功能的活性物质和生物制品。这项研发工作的更广泛意义包括以下几个方面：首先，除了农作物保护产品之外，这里开发的输送系统预计将在针对消费者、建筑市场和医疗保健的许多产品中找到商业应用。其次，良性小结构的制定有可能在各种工业环境中取代各种持久性和有害的纳米颗粒，这将增强对纳米尺度可扩展过程的科学和技术理解。第三，该项目开发的可持续解决方案可以加强现有自然资源，增强美国食品供应的生物安全，并改善公众健康。该 SBIR 第一阶段项目提议设计一个创新系统，以高效输送农业活性物质。为了提高生产力，当前的农业实践使用大量的作物保护化学品。然而，农用化学品的密集使用造成了环境威胁，破坏了自然资源，并可能导致气候变化。为了应对这些挑战，我们正在开发创新、突破性的平台技术，有可能以相同或更少的投入提高农业效率，同时保护环境。这项工作的目标是基于广泛可用、可生物降解和生物可再生的木质素，创造一类新型可扩展、功能活跃、可持续和环保的材料。该项目的第一个目标是建立一个连续流程来制备用少量活性杀菌剂功能化的木质素颗粒。这项研究将为这些制剂的连续配制提供可行性。该研究的第二个目标包括使用一系列抗菌和抗真菌测定来表征新配方。第一阶段工作的结果是，通过确定第二阶段进行实地研究最有希望的配方，可以降低技术风险。