SBIR Phase I: Lignin-Based Formulations for Efficient and Sustainable Control of Plant Pathogens

SBIR 第一阶段：基于木质素的制剂，用于有效和可持续地控制植物病原体

• 批准号: 1746692
• 负责人: Anka Veleva
• 金额: $ 22.5万
• 依托单位: BENANOVA Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1746692&HistoricalAwards=false
• 关键词: SBIR; Phase; Lignin; Based; Formulations

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project encompasses the development of a continuous fabrication process to enable production of larger volumes of the next generation of agrochemical compounds. Although the first focus is on utilization for efficient delivery of antimicrobial and antifungal crop protection chemicals, this platform can be applied for actives and biologicals with other functionalities. The broader significance of this research and development effort entails the following aspects: First, in addition to agricultural crop protection products, the delivery system developed here is expected to find commercial applications in many products targeted to the consumer, construction markets, and healthcare. Second, the formulation of benign small structures that have the potential to replace a wide range of persistent and harmful nanoparticles in various industrial settings will enhance scientific and technological understanding of scalable processes on the nanoscale. Third, the sustainable solutions developed in this project could strengthen existing natural resources, enhance biosecurity of the U.S. food supply, and improve public health. This SBIR Phase I project proposes to engineer an innovative system for efficient delivery of agricultural actives. To increase productivity, current agricultural practices utilize large amounts of crop protection chemicals. However, the intensive use of agrochemicals creates environmental threats damaging natural resources and potentially causing climate change. To address these challenges we are developing innovative, breakthrough platform technology with potential to increase efficiency of farming with the same or fewer inputs, while protecting the environment. The goal of this work is to create a new class of scalable, functionally active, sustainable and eco-friendly materials based on the widely available, biodegradable and bio-renewable resource lignin. The first objective of the project is to build a continuous flow process for preparation of lignin particles functionalized with small amounts of active biocides. This research will establish feasibility for continuous formulation of these preparations. The second objective of the study includes characterization of the new formulations using a series of antimicrobial and antifungal assays. As a result of the Phase 1 effort, technical risk will be reduced by identifying the most promising formulations for field studies to be conducted in Phase 2.

这项小型企业创新研究（SBIR）项目的更广泛的影响/商业潜力涵盖了连续制造过程的开发，以产生大量的下一代农业化合物。尽管第一个重点是利用有效地递送抗菌和抗真菌作物保护化学品，但该平台可以用于具有其他功能的活性和生物学。这项研究和发展工作的更广泛的意义需要以下方面：首先，除了农业作物保护产品外，此处开发的交付系统有望在许多针对消费者，建筑市场和医疗保健的产品中找到商业应用。其次，在各种工业环境中，有可能替代各种持久和有害纳米颗粒的良性小结构的制定将增强对纳米级可扩展过程的科学和技术理解。第三，该项目中开发的可持续解决方案可以增强现有的自然资源，增强美国粮食供应的生物安全并改善公共卫生。该SBIR I期项目提议为有效地提供农业活性的创新系统。为了提高生产率，当前的农业实践利用大量的作物保护化学物质。但是，大量使用农化学物质会造成环境威胁损害自然资源，并可能导致气候变化。为了应对这些挑战，我们正在开发创新的突破性平台技术，并有可能在保护环境的同时提高相同或更少的投入的农业效率。这项工作的目的是基于广泛可用，可生物降解和生物可再生资源木质素的新型可扩展，功能性，可持续和环保的材料。该项目的第一个目的是建立一个连续的流动过程，以制备用少量活性杀菌剂功能化的木质素颗粒。这项研究将确定连续制定这些制剂的可行性。该研究的第二个目标包括使用一系列抗菌和抗真菌测定法对新制剂进行表征。由于第1阶段的工作，通过确定在第2阶段进行现场研究的最有希望的表述，将降低技术风险。