SBIR Phase I: Robust Nanofiltration to Enable Challenging Chemical and Pharmaceutical Separations

SBIR 第一阶段：强大的纳滤技术可实现具有挑战性的化学和药物分离

• 批准号: 1722157
• 负责人: Shreya Dave
• 金额: $ 22.5万
• 依托单位: Via Separations, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1722157&HistoricalAwards=false
• 关键词: SBIR; Phase; Robust; Nanofiltration; Enable

The broad impact of the proposed SBIR project is in the development of Graphene oxide based filtration membranes in industrial applications, such as pharmaceutical and chemical production. Current polymer membranes are not meeting specific industrial needs and are unlikely to do so with incremental innovation. On the other hand, converting from distillation and evaporation to membrane-based separation has the potential to reduce energy consumption in the US by 10%. The proposed graphene oxide based material is a robust nanomaterial that is capable of separating streams at the molecular level while withstanding the challenging environments of chemical separations. Successful implementation will increase process intensification and energy efficiency for pharmaceutical and chemical producers, while simultaneously enabling previously inaccessible separations. Graphene Oxide (GO) membranes enable a new materials platform for fine liquid filtration in harsh environments. These temperature stable, solvent resistant, and oxidizer tolerant membranes will accomplish nanofiltration (NF) separation of a range of feed streams. With immediate benefits in reducing cleaning time and downtime for dairy and food production and high impact for energy savings in pharmaceutical and chemical separations, materials innovation for membranes represents a large opportunity for energy and cost savings. GO is synthesized at near ambient temperatures with low-cost synthetic chemistry methods and thus is many orders of magnitude less expensive than graphene. This proposal focuses on further developing the graphene oxide material for the high value pharmaceutical and chemical streams in order to transition from heat-based or low-throughput distillation, evaporation, and chromatography methods towards the significantly lower cost and energy-efficient membrane alternative.

拟议的SBIR项目的广泛影响是在工业应用中（例如药物和化学生产）中基于氧化石墨烯的过滤膜的发展。 当前的聚合物膜无法满足特定的工业需求，并且不太可能通过增量创新来做到这一点。另一方面，从蒸馏和蒸发转换为基于膜的分离有可能将美国的能源消耗降低10％。 提出的基于氧化石墨烯的材料是一种可靠的纳米材料，能够在分子水平分离流，同时承受化学分离的挑战性环境。成功的实施将提高药物和化学生产者的过程强化和能源效率，同时实现以前无法接近的分离。 氧化石墨烯（GO）膜在恶劣的环境中为精细液体过滤提供了一个新的材料平台。这些温度稳定，抗溶剂和氧化剂耐受膜将完成一系列进料流的纳米滤过（NF）分离。在减少乳制品和粮食生产的清洁时间和停机时间方面的好处，以及在药物和化学分离中节省能源的高影响，膜的材料创新代表了节能和成本节省的巨大机会。使用低成本合成化学方法的GO是在接近环境温度下合成的，因此比石墨烯便宜得多的数量级。 该提案着重于进一步开发高价值药物和化学流的石墨烯氧化物材料，以从基于热的或低通量蒸馏，蒸发和色谱法转变为成本和能源效率较低的膜替代品。