SBIR Phase I: Medical Devices for Real-time Radiation Dosimetry at Sub-millimeter Spatial Resolution

SBIR 第一阶段：用于亚毫米空间分辨率实时辐射剂量测量的医疗设备

• 批准号: 1721296
• 负责人: David Lewis
• 金额: $ 22.5万
• 依托单位: eBeam Film LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1721296&HistoricalAwards=false
• 关键词: SBIR; Phase; Medical; Devices; Real; SBIR; Phase; Medical; Devices; Real

This Small Business Innovation Research Phase I project seeks development of a novel dosimeter for 2-D mapping of radiation dose in real-time at sub-millimeter spatial resolution. The high spatial resolution of the dosimeter is essential in supporting stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) treatments. These rapidly emerging modalities deliver precise doses of radiation to small, well defined treatment sites while minimizing exposure of critical neighboring anatomy. With the annual number of SRS/SBRT treatments approaching 1,000,000 and growing 5-10% annually there is a market need for a dosimeter with sub-millimeter resolution and the capability of measuring in real-time. The routine pre-treatment verification of each patient therapy plan becomes a target application. The value of the market for the dosimeter alone exceeds $10 million annually. The value is amplified through enablement of the safe and efficacious delivery of SRS and SBRT treatments. Use of these modalities greatly impacts the efficiency of radiotherapy by substantially reducing the number of individual sessions in a course of treatment. The net result is lower cost for the treatment course, an increase in the number of patients/year for each linear accelerator equipment unit and a large reported improvement in patient outcomes. The intellectual merit of this project lies in combining and adapting key elements of two well-established commercial technologies, piezoelectric polymers and radiochromic film, to produce a hybrid dosimeter. This dosimeter preserves the high spatial resolution of radiochromic film while improving its usability by making the changes caused by radiation exposure to become detectable by electronic means in real-time. During use, the flexible, single-use piezoelectric array dosimeter (PARD) fits into a re-usable data acquisition electronics module that transmits a map of measured doses to a Medical Physicist outside the radiation cell. Radiochromic film, the only current dosimeter with sub-millimeter spatial resolution, is inconvenient owing to the long delay between exposure and measurement as well as the extra time and effort in facilitating the measurements. This drawback adversely impacts its usefulness in the day-to-day verification of patient treatment plans. The hybrid PARD product provides a dense, flexible array (0.1 mm spacing) of detectors with the unique ability for dose measurement at sub-millimeter resolution in real time. This overcomes key drawbacks of existing electronic array devices which are incapable of spatial resolution below 5 mm and unsuitable for the small radiation fields associated with SRs and SBRT treatments.

这个小型企业创新研究阶段I项目寻求开发新型的剂量计，以实时在亚毫米空间分辨率下实时实时地辐射剂量。剂量计的高空间分辨率对于支持立体定向放射外科手术（SRS）和立体定向身体放射治疗（SBRT）治疗至关重要。这些快速新兴的方式将精确的辐射剂提供给小的，定义明确的治疗部位，同时最大程度地减少关键的邻近解剖结构的暴露。随着SRS/SBRT治疗的年数接近1,000,000，并且每年增加5-10％，因此市场需要具有亚毫米分辨率的剂量计，并且实时测量能力。每个患者治疗计划的常规预处理验证成为目标应用。仅剂量表的市场价值每年超过1000万美元。通过实现SRS和SBRT处理的安全有效递送，可以放大该值。 这些方式的使用极大地影响了放射疗法的效率，从而大大减少了治疗过程中的个体疗程数量。最终结果是治疗过程的成本较低，每个线性加速器设备单元的患者/年数量增加，并且报告的患者预后有很大的改善。 该项目的智力优点在于结合和调整两种良好的商业技术，压电聚合物和放射性膜的关键要素，以产生混合剂​​量列表。该剂量计保留了放射性薄膜的高空间分辨率，同时通过使辐射暴露引起的变化可实时检测到可用性。在使用过程中，柔性，一次性的压电阵列剂量仪（PARD）拟合到可重复使用的数据采集电子模块中，该模块将测量剂量的地图传输到辐射电池外的医疗物理学家。放射性膜是唯一具有亚毫米空间分辨率的当前剂量计，由于暴露和测量之间的延迟以及促进测量值的额外时间和精力，这是不便的。这种缺点会不利影响其在日常验证患者治疗计划中的用处。混合式pard产品提供了探测器的密集，柔性阵列（0.1 mm间距），具有独特的剂量测量能力，可实时测量剂量测量。这克服了现有电子阵列设备的关键缺点，这些设备无法以低于5 mm的空间分辨率，不适合与SRS和SBRT处理相关的小辐射场。