PFI: BIC: WearNet: Wearable Nanoplasmonic Biosensing Networks for Smart Health Monitoring & Diagnosis

PFI：BIC：WearNet：用于智能健康监测的可穿戴纳米等离子体生物传感网络

基本信息

批准号：
1718177
负责人：
Josep Jornet
金额：
$ 100万
依托单位：
SUNY at Buffalo
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2022-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1718177&HistoricalAwards=false
关键词：
PFI BIC WearNet Wearable Nanoplasmonic

项目摘要

Major advancements in the fields of electronics, photonics, electro-mechanical systems and wireless communication have enabled the development of compact wearable devices, with applications in diverse domains such as fitness, wellness and medicine. Despite their potential, existing wearable devices are only able to measure a few parameters (e.g., heart rate, breathing, temperature or blood pressure). In parallel to these efforts, nanotechnology is enabling the development of miniature sensors that can detect different types of human health events at the nanoscale with unprecedented accuracy. In-vivo nanosensing systems, which can operate inside the human body in real time, have been proposed as a way to provide faster and more accurate disease diagnosis over traditional technologies. Despite the potential of this technology, there are several limitations in the current systems, such as the cost and bulkiness of existing portable systems, which limit its real-world impact. The objective of this project is to develop a smart service system for advanced health monitoring and disease diagnosis based on wearable nano-biosensing networks. The system consists of three elements: 1) a nanoplasmonic biochip, to be implanted under the skin and designed to react to lung cancer biomarkers; 2) a wearable smart band, integrated by nanophotonic devices for excitation and measurement of the implant; and 3) a software platform to process the measured signals, extract the information, and formulate a diagnosis. This technology will significantly boost the applications of wearable devices, by providing the means to detect different types of diseases and, in particular, cancer. By partnering with two industry leaders and pioneers in the fields of solid-state electronics and advanced biomedical devices, this project is expected to enable cancer progression monitoring systems, with a broad societal impact. Importantly, integrating research and industry with education is a priority in this interdisciplinary effort, which will train the next generation of student scientists (6 doctoral students supported). The project encompasses four intertwined research thrusts. The first thrust is focused on the development of the nanoplasmonic biosensing technology at the basis of this smart health system. This includes an implantable nanoplasmonic biochip composed of multiplexed sensor arrays for lung cancer detection from biomarkers in blood, as well as the optical nano-sources and nano-photodetectors needed to respectively excite and measure the biosensing signals through reflection, both integrated in a wearable device. The second thrust is focused on the development of the software algorithms to dynamically calibrate and operate the nano-sources, collect and post-process the measured signals at the nano-photodetectors by considering the intra-body wireless channel, extract the diagnose information and securely share the collected data with the healthcare provider. The third thrust is focused on the human factors that impact the design of the entire system, including the study of the impact and optimization of the nanoplasmonic biochip in biological tissues, the development of biochip regeneration techniques for continued operation of the implant, the investigation of the photothermal effects introduced by the nanophotonic excitation platform and the implant, and the processing and distribution of sensitive data related to the users' health. Finally, the fourth thrust will create an integrated testbed for the entire proposed system, involving in-vitro testing of the biochips with blood samples of lung cancer patients, ex-vivo testing with biochips implanted in tissue-equivalent phantoms with blood microcirculation networks, and testing in cadaver specimens.The project is led by an interdisciplinary team of researchers at the University at Buffalo with participation of the Departments of Electrical Engineering, Chemical and Biomedical Engineering and Orthopedics. Two industry partners contribute and support the development of this project, Intel Labs (Hillsboro, Oregon, large business partner) and Garwood Medical Devices (Buffalo, NY, start-up partner). In addition, the Roswell Park Cancer Institute (Buffalo, NY), a cancer research and treatment center, serves as a broader context partner and consultant to the team.

电子，光子学，电力系统和无线通信领域的主要进步使紧凑型可穿戴设备的开发以及在健身，健康和医学等不同领域中的应用。尽管具有潜力，但现有的可穿戴设备只能测量一些参数（例如，心率，呼吸，温度或血压）。与这些努力并行，纳米技术正在实现微型传感器的发展，这些传感器可以以前所未有的精度检测纳米级的不同类型的人类健康事件。已经提出，可以实时在人体内部运行的体内纳米传感系统，是一种提供对传统技术的更快，更准确疾病诊断的一种方式。尽管这项技术具有潜力，但当前系统中存在一些局限性，例如现有便携式系统的成本和笨重，这限制了其现实世界的影响。该项目的目的是开发一种智能服务系统，用于基于可穿戴纳米生物传感网络的高级健康监测和疾病诊断。该系统由三个元素组成：1）纳米质生物芯片，将植入皮肤下方，并旨在对肺癌生物标志物反应； 2）可穿戴的智能带，由纳米光子设备集成，以激发植入物的激发和测量； 3）处理测量信号，提取信息并制定诊断的软件平台。这项技术将通过提供检测不同类型的疾病，尤其是癌症的方法来大大提高可穿戴设备的应用。通过与固态电子和先进生物医学设备领域的两名行业领导者和开拓者合作，该项目有望使癌症进展监测系统能够产生广泛的社会影响。重要的是，将研究和行业与教育相结合是这项跨学科工作的优先事项，该工作将培训下一代学生科学家（受支持的6名博士生）。该项目包括四个相互交织的研究推力。第一个推力重点是基于该智能卫生系统的纳米质生物传感技术的开发。其中包括一个由多重传感器阵列组成的可植入纳米质体生物芯片，可从血液中的生物标志物以及光学纳米源和纳米光探测器组成，以分别激发并通过反射进行反射，均分别激发并测量生物并发信号。第二个推力集中在软件算法的开发上，以动态校准和操作纳米源，收集和后处理，通过考虑体内无线通道，提取诊断信息并牢固地提取诊断信息，并在纳米光探测器上进行测量的信号与医疗保健提供者共享收集的数据。第三个推力集中在影响整个系统设计的人为因素上，包括研究纳米质子生物芯片在生物组织中的影响和优化，生物芯片再生技术的发展用于植入物的持续运行，研究纳米光激发平台和植入物引入的光热效应以及与用户健康相关的敏感数据的处理和分布。最后，第四个推力将为整个提出的系统创建一个集成的测试床，涉及对肺癌患者血液样本对生物芯片进行体外测试，并用植入组织等效幻象的生物芯片和血液微循环网络和血液中的微循环网络和血液中的生物芯片进行前的生物芯片，以及该项目由布法罗大学大学的研究人员组成，由电气工程，化学和生物医学工程和骨科部门参与。两个行业合作伙伴贡献并支持该项目的开发，即英特尔实验室（Hillsboro，俄勒冈州，大型商业伙伴）和Garwood Medical Devices（纽约州布法罗，启动合作伙伴）。此外，癌症研究与治疗中心的罗斯威尔公园癌症研究所（Roswell Park Cancer Institute（Buffalo），纽约州布法罗（Buffalo），是该团队的更广泛的背景合作伙伴和顾问。