SusChEM: Bimetallic Catalysis for C-C and C-X Bond Formation

SusChEM：用于 C-C 和 C-X 键形成的双金属催化

基本信息

批准号：
1664632
负责人：
Neal Mankad
金额：
$ 45万
依托单位：
University of Illinois at Chicago
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2021-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1664632&HistoricalAwards=false
关键词：
SusChEM Bimetallic Catalysis Bond Formation

项目摘要

Replacing precious metal catalysts with those using inexpensive and abundant metals is a major challenge faced by the chemistry community as precious metal resources dwindle and the focus on the environmental impact of chemical manufacturing increases. Successfully utilizing non-precious metal catalysts improves the sustainability, economics, and environmental impact of many technologies that are crucial to society. However, accomplishing this requires the development of new non-precious catalysts that function as well as, or better than, established precious metal catalysts. In this project, Dr. Mankad is developing a new strategy for catalyzing reactions of importance to the synthesis of fine chemicals and pharmaceuticals. The concept uses two non-precious metals to achieve chemical reactions typically conducted with a single precious metal. In addition to achieving the targeted chemical reactions, development of these innovative catalysts stands to impact many other areas of chemistry that rely on catalysis. Dr. Mankad is leading a diverse team of researchers and is promoting their engagement in outreach and leadership activities in their university and community. These activities, which include conducting chemistry demonstrations for urban middle school students in Chicago, promoting laboratory safety in research and teaching settings, and disseminating research results to a wide range of audiences, are promoting both interest in STEM disciplines and engagement in the issues of sustainability and environmental responsibility.With funding from the Chemical Catalysis Program of the Chemistry Division, Dr. Mankad of the University of Illinois at Chicago (UIC) is developing bimetallic strategies for C-C and C-X coupling reactions that utilize two base metals cooperatively to achieve transformations typically conducted using single-site noble metal catalysts. The targeted transformations include carbonylative C-C coupling reactions (typically catalyzed by Pd) that allow for the modular synthesis of ketone products from simple starting materials, dehydrogenative C-H borylation reactions (typically catalyzed by Ir) that allow for direct synthesis of arylboronic esters that are valuable synthetic building blocks, and alkyne semi-hydrogenation reactions (typically catalyzed by Pd, Ru, Rh, Ir) that exhibit unusual stereoselectivity dictated by the bimetallic reaction mechanism. The cooperation of two or more metals during catalysis is an under-developed design strategy, and so this project stands to have a broad impact on many other areas of chemistry that depend on catalysis. Dr. Mankad leads a diverse team of researchers and promotes their participation in outreach and leadership activities at UIC and in the surrounding Chicago community, including outreach to local middle school students, promotion of laboratory safety, and engagement in issues of sustainability and environmental responsibility, that further support the broader impacts of the project.

用贵金属催化剂代替贵金属催化剂，这是化学界面临的重大挑战，因为贵金属资源逐渐减少，并且关注化学制造的环境影响增加。成功利用非私致金属催化剂改善了许多对社会至关重要的技术的可持续性，经济性和环境影响。但是，实现这一目标需要开发新的非偏心催化剂，这些催化剂的功能，或者比已建立的贵金属催化剂更好或更好。在这个项目中，曼卡德博士正在制定一种新的策略，以促进对精细化学物质和药品的合成重要性的反应。该概念使用两种非私致金属来实现通常用单个贵金属进行的化学反应。除了实现靶向化学反应外，这些创新催化剂的发展还会影响依赖催化的许多其他化学领域。曼卡德（Mankad）博士领导着一个多元化的研究人员团队，并正在促进他们在大学和社区中的外展和领导活动的参与。这些活动包括为芝加哥的城市中学学生进行化学演示，促进研究和教学环境中的实验室安全，以及将研究结果传播到广泛的受众群体中，都在促进对STEM学科的兴趣和参与可持续性和环境责任的问题。 C-C和C-X耦合反应利用两种基本金属合作实现通常使用单位贵金属催化剂进行的转换。 The targeted transformations include carbonylative C-C coupling reactions (typically catalyzed by Pd) that allow for the modular synthesis of ketone products from simple starting materials, dehydrogenative C-H borylation reactions (typically catalyzed by Ir) that allow for direct synthesis of arylboronic esters that are valuable synthetic building blocks, and alkyne semi-hydrogenation reactions (typically catalyzed by Pd，ru，rh，ir）表现出由双金属反应机制决定的异常立体选择性。催化过程中两种或多种金属的合作是一种欠发达的设计策略，因此该项目对依赖催化的许多其他化学领域产生了广泛的影响。曼卡德（Mankad）博士领导了一个多元化的研究人员团队，并促进了他们在UIC和周围芝加哥社区的宣传和领导活动的参与，包括向当地中学学生推广，促进实验室安全以及参与可持续性和环境责任的问题，以进一步支持该项目的广泛影响。