SEES Fellows: Recyclable Solid Supports as a Sustainable Platform Technology

SEES 研究员：可回收固体支撑物作为可持续平台技术

• 批准号: 1655581
• 负责人: Frank Leibfarth
• 金额: $ 7.33万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1655581&HistoricalAwards=false
• 关键词: SEES; Fellows; Recyclable; Solid; Supports

In this Award from the NSF Science, Engineering and Education for Sustainability Fellows (SEES Fellows Program) Dr. Frank Leibfarth from the Massachusetts Institute of Technology will develop recyclable solid supports for the efficient and economical production of complex molecules, including polysaccharides, peptides and oligonucleotides. This award has support from: the Directorate for Engineering; and the Division of Chemistry and the Division of Materials Science in the Directorate for Mathematical and Physical Sciences.The proposed work will combine solid phase synthesis on a polymer support with dynamic covalent chemistry with a continuous flow system to carry out the reactions that create the target molecules. The aim of studies like that proposed in this work is to develop better, more efficient methods for the synthesis of complex molecules (e.g. pharmaceuticals) with minimum production of chemical waste.Dr. Leibfarth will be working with collaborators Prof. Timothy F. Jamison of the Department of Chemistry at the Massachusetts Institute of and Dr. Sejal Patel of Novartis Institutes of Biomedical Research. Dr. Leibfarth will also work with the MIT Office of Engineering Outreach as well as the Society of Hispanic Professional Engineers on educational projects. This project is supported under the NSF Science, Engineering and Education for Sustainability Fellows (SEES Fellows) program, with the goal of helping to enable discoveries needed to inform actions that lead to environmental, energy and societal sustainability while creating the necessary workforce to address these challenges. With SEES Fellows support, this project will enable a promising early career researcher to establish themselves in an independent research career related to sustainability.

NSF科学，可持续性研究员工程和教育（SEE FELLOWS计划）在这一奖项中，马萨诸塞州理工学院的Frank Leibfarth博士将为有效且经济地生产复杂分子（包括多糖，肽，肽，肽和寡核苷酸）提供可回收可回收的固体支持。 该奖项得到了：工程局的支持；以及在数学和物理科学局中化学和材料科学的划分。拟议的工作将在聚合物支持上的固相合成与动态共价化学与连续流动系统结合起来，以执行创建目标分子的反应。这项工作中提出的类似研究的目的是为合成复杂分子（例如药物）的合成而开发出更好，更有效的方法，并以最少的化学废物产生。 Leibfarth将与马萨诸塞州化学系的蒂莫西·F·贾米森（Timothy F. Leibfarth博士还将与MIT工程外展办公室以及西班牙裔专业工程师协会合作。该项目得到了NSF科学，工程和可持续性研究员教育（SEES Fellows）计划的支持，目的是帮助实现所需的发现，以告知导致环境，能源和社会可持续性的行动，同时创造必要的劳动力来应对这些挑战。借助See Fellows的支持，该项目将使有前途的早期职业研究员能够在与可持续性有关的独立研究职业中建立自己。