Doctoral Dissertation Research: The Influence of Infant-Caregiver Feeding Interactions on Diet, Growth and Metabolic Development

博士论文研究：婴儿与照顾者喂养互动对饮食、生长和代谢发育的影响

• 批准号: 1650751
• 负责人: Amanda Thompson
• 金额: $ 3.02万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1650751&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Influence; Infant

Research in human biology has provided evidence that early life factors shape later life outcomes through biological mechanisms. This dissertation research project will investigate linkages between physiological and nutritional aspects of early life and the risk of childhood and adult obesity, with a specific focus on diet, appetite and growth during the first year of life. The results will shed light on what kinds of diets during infancy might reduce obesity risk, and on social factors that help families make more optimal dietary choices. The project addresses fundamental questions in life history theory, and will be relevant to the well-being of the US population, for which obesity rates continue to increase. Data will be shared with clinical practitioners who advise families from all types of social backgrounds about nutrition for their children, and policy makers who focus on improving access to adequate nutrition for young children and their families. The project will also support student training in STEM research at the undergraduate and graduate levels.This project integrates social determinants of health and developmental origins of health and disease frameworks to investigate how social contexts influence access to nutrition and information about nutrition, and how the nutrition infants experience shapes long-term health. It also uses the concept of the developmental niche to explore how caregiver observations of infant growth and family mealtime interactions influence what and how infants eat. The investigator will follow Latino families with young infants from 3 to 12 months of age. Ethnographic interviews will be conducted to understand what kinds of factors influence how and what parents feed their infants. Survey and observational data will be collected to understand how infant appetite and mealtime interactions influence what and how much infants eat. Growth hormones and infant growth measurements will be collected to understand how infants' diets influence their growth and growth hormones. Appetite hormone analysis will be completed to understand how appetite hormones influence and are influenced by infant nutrition. The findings will illuminate how social contexts, family behaviors and infant biology are intertwined in ways that may influence obesity risk.

人类生物学的研究提供了证据，表明早期生命因素通过生物学机制塑造了以后的生活结果。该论文研究项目将调查早期生命的生理和营养方面与儿童肥胖的风险之间的联系，并在生命的第一年中特别关注饮食，食欲和增长。结果将阐明婴儿期间哪种饮食可能会降低肥胖风险，以及帮助家庭做出最佳饮食选择的社会因素。该项目解决了生活历史理论中的基本问题，并将与美国人口的福祉有关，肥胖率继续增加。数据将与临床从业人员共享，他们为各种社会背景的家庭提供有关其孩子营养的建议，以及专注于改善幼儿及其家人足够营养的决策者。该项目还将支持本科和研究生级别的STEM研究培训。该项目融合了健康和疾病框架的健康和发展起源的社会决定因素，以研究社会环境如何影响营养和营养的信息，以及营养婴儿如何体验长期健康。它还使用发育利基的概念来探讨照顾者对婴儿生长和家庭进餐时间互动的观察如何影响婴儿的饮食和方式。调查人员将跟随拉丁裔家庭，年龄在3至12个月大的孩子中。将进行民族志访谈，以了解哪些因素会影响父母的养育方式和何种因素。将收集调查和观察数据，以了解婴儿的食欲和进餐时间相互作用如何影响婴儿的饮食。将收集生长激素和婴儿生长测量，以了解婴儿饮食如何影响其生长激素。食欲激素分析将完成，以了解食欲激素如何影响并受婴儿营养的影响。这些发现将阐明社会环境，家庭行为和婴儿生物学如何以可能影响肥胖风险的方式交织在一起。