EAGER: Integrating Multiple Biomarkers in Nano-Sensor Arrays for Enhanced Detection of Prostate Cancer

EAGER：将多种生物标记物集成到纳米传感器阵列中以增强前列腺癌的检测

• 批准号: 1649934
• 负责人: Frances Williams
• 金额: $ 30万
• 依托单位: Tennessee State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1649934&HistoricalAwards=false
• 关键词: EAGER; Integrating; Multiple; Biomarkers; Nano

The National Science Foundation uses the Early-concept Grants for Exploratory Research (EAGER) funding mechanism to support exploratory work in its early stages on untested, but potentially transformative, research ideas or approaches. This EAGER project was awarded as a result of the invitation in the Dear Colleague Letter NSF 16-080 to proposers from Historically Black Colleges and Universities to submit proposals that would strengthen research capacity of faculty at the institution. The project at Tennessee State University aims to design and develop nano-cantilever resonators functionalized with multiple biomarkers to provide for an accurate, highly sensitive, fast, and low-cost method for the detection of prostate cancer.This project seeks to explore the feasibility of integrating multiple biomarkers in a nano-cantilever array to provide for an accurate, highly sensitive, fast, and low-cost method for the detection of prostate cancer. The sensor cantilever array will be designed and fabricated, each cantilever will be functionalized with a different biomarker, and the response from the array will be measured and mapped together to provide a model for detecting prostate cancer. It is proposed that the sensor array will generate more data about the sample to be analyzed and provide for a more accurate and specific detection method, reducing the number of false positives generated. The main tasks to be completed to achieve this objective are: the design of the nano-cantilevers; fabrication of the nano-electromechanical systems devices; functionalizing the nano-resonator surfaces, including the conjugation of the gold nanoparticles with each of the four biomarkers to be used and the application of each bio-substrate on a nano-cantilever; and testing of the nano-cantilever array. This work could be expanded in the future to provide a framework for the use of multiple biomarkers for other sensing mechanisms where specificity and sensitivity are an issue. This EAGER project is funded by the Engineering Directorate.

美国国家科学基金会（National Science Foundation）使用早期概念赠款进行探索性研究（急切）资金机制，以在未经测试但可能具有变革性的研究思想或方法的早期阶段支持探索性工作。这项渴望的项目是由于尊敬的同事信函NSF 16-080向历史悠久的黑人学院和大学提出的提议提出的提议提出的提议，以提高该机构的研究能力。田纳西州立大学的项目旨在设计和开发与多个生物标志物功能功能功能的纳米范围谐振器，以提供一种准确，高度敏感，快速和低成本的方法来检测前列腺癌。该项目旨在探索在nano-cantilever array中的可行性，以探索具有高度敏感性的可行性，以使其具有高度敏感性的敏感性，并具有敏感性的敏感性，并可以快速地构成敏感性，并可以探索敏感性的敏感性，并探索快速敏感的敏感性。 癌症。传感器悬臂阵列将进行设计和制造，每个悬臂将使用不同的生物标志物进行功能化，并且将测量和映射阵列的响应，以提供检测前列腺癌的模型。建议传感器阵列将生成有关要分析的样品的更多数据，并提供更准确，更具体的检测方法，从而减少了产生的假阳性数量。 实现这一目标的主要任务是：纳米 - 委托人的设计；制造纳米电力机械系统设备；功能化纳米谐振器表面，包括将金纳米颗粒与要使用的四种生物标志物中的每一个结合以及每个生物底物在纳米范围内的应用；和纳米范围阵列的测试。 将来可以扩展这项工作，以提供使用多个生物标志物来用于其他感应机制的框架，在这些传感机制中，特异性和敏感性是问题。这个渴望的项目由工程局资助。