Collaborative Research: RUI: Three-Dimensional Multiphysics Simulation of Multi-phase Flows with Magnetic Fluids

合作研究：RUI：磁流体多相流的三维多物理场仿真

• 批准号: 1620152
• 负责人: Avrom Trubatch
• 金额: $ 9.82万
• 依托单位: Montclair State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1620152&HistoricalAwards=false
• 关键词: Collaborative; Research; RUI; Three; Dimensional

Advances in the synthesis of Ferrofluids (engineered fluids that respond to magnetic fields and have a number of well-established industrial applications) have increased the scope of potential applications of these fluids to new areas. Emerging applications of ferrofluids include: magnetic targeting of drugs, cell sorting in biomedical systems and magnetically driven contaminant removal. In each of these applications the use of ferrofluids enables new techniques that depend on the use of magnetic fields for 'remote control' of the ferrofluid. However, the realization of such technologies is hampered by complexities in the simulation of these systems for further development and design. The proposed research program includes the development of effective, robust computational tools that will enable such simulations. In particular, the computing codes will include the particular magnetic physics of ferrofluids as well as the forces resulting from the magnetic fields, which serve as the means of control in these applications. The development of these effective simulation tools will support and accelerate innovation in these emerging technologies. Moreover, the proposed program of code development, simulations and integrated physical experiments will serve as a proof-of-concept for the inclusion of realistic multiphysics fluid simulations for complex scientific and engineering applications. The proposed research program will involve undergraduate and masters-degree students in leading-edge research, including students who are members of groups under-represented in STEM disciplines such as women and first-generation college students.In magnetic drug targeting, a ferrofluid whose constituent nanoparticles have been functionalized to carry theraputic drugs is directed to a tumor or other localized site (e.g., in the eye); sorting of(nonmagnetic) biological cells by immersion in a ferrofluid so that the force of an applied magnetic field depends on cell size; purification of a polluted fluid by adsorption of contaminants to magnetic nanoparticles, which are then separated from the fluid by magnetic forces. However, advances in these applications are stymied by the complex, multi-scale and multi-physics nature of the fluid-dynamical systems in which they occur. In particular, because contemporary fluid-dynamics codes are not designed to incorporate the additional physics of magnetic-fluid systems, effective simulation with these codes is difficult. The proposal describes a plan to develop and test a new parallel, multi-phase code for fully three-dimensional flows. This project will lead to a flexible and efficient, multi-phase magnetic-fluid simulation code that is fully three-dimensional and parallelized for high-performance computing. Hence, the code will enable realistic simulations relevant to the significant applications addressed. Specifically, in order to address the above-noted applications, the code will model and simulate flows with dynamic interfaces between the ferrofluid and other fluids. Moreover, the code will implement models of viscosity effects (magnetoviscosity) as well as driving forces that result from applied magnetic fields (magnetophoresis) in a flexible manner that simplifies adjustment and update of the models.

合成铁体流体的进步（对磁场响应并具有许多公认的工业应用的工程流体）提高了这些流体在新区域的潜在应用的范围。铁洛群的新兴应用包括：药物的磁靶向，生物医学系统中的细胞分选以及磁驱动的污染物去除。在这些应用中，铁氟烷的使用实现了依赖于使用磁场来“远程控制”铁漏的新技术。但是，在这些系统的模拟中，复杂性以进行进一步开发和设计，这种技术的实现受到了阻碍。拟议的研究计划包括开发有效，可靠的计算工具，这些工具将启用此类模拟。特别是，计算代码将包括铁体流体的特定磁性物理以及磁场引起的力，这些磁场是这些应用中的控制手段。这些有效的仿真工具的开发将支持和加速这些新兴技术的创新。此外，拟议的代码开发，模拟和集成的物理实验计划将作为概念概念，以将现实的多物理流体模拟用于复杂的科学和工程应用。拟议的研究计划将涉及本科生和硕士学位学生参与领先的研究，其中包括在诸如女性和第一代大学生等STEM学科中代表性不足的成员的学生。在磁性药物靶向中，铁铁素养（一种将其组成的纳米颗粒的纳米颗粒都用于治疗药物的作用（将其定向），或者将其定向（均为其他景点）。通过将（非磁性）生物细胞浸入铁氟烷中，以使施加的磁场的力取决于细胞大小。通过吸附污染物对磁性纳米颗粒的吸附来纯化污染的液体，然后通过磁力将其与流体分离。但是，这些应用中的进步受到了发生的流体动力系统的复杂，多尺度和多物理性质的阻碍。特别是，由于当代流体动力学代码并非旨在结合磁性流体系统的其他物理，因此很难使用这些代码进行有效的模拟。该提案描述了一个计划，以制定和测试一个全面三维流的新的平行，多相代码。该项目将导致灵活，高效的多相磁性型仿真代码，该代码完全三维且平行于高性能计算。因此，该代码将启用与所解决的重要应用程序相关的现实模拟。具体而言，为了解决上述应用程序，该代码将模拟和模拟流动界面和其他流体之间的动态接口。此外，该代码将以灵活的方式实现粘度效应（磁性粘度）的模型（磁性粘度）以及施加的磁场（磁载体）产生的驱动力，从而简化了模型的调整和更新。