Demonstration and Applications of Single Molecule Magnetic Resonance Spectroscopy at Physiological Conditions

生理条件下单分子磁共振波谱的演示和应用

• 批准号: 1611134
• 负责人: Susumu Takahashi
• 金额: $ 39万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1611134&HistoricalAwards=false
• 关键词: Demonstration; Applications; Single; Molecule; Magnetic

With support from the Chemical Measurement & Imaging (CMI) and the Chemical Structure, Dynamics, & Mechanisms - A (CSDM-A) Programs in the Division of Chemistry, Dr. Susumu Takahashi and his group at the University of Southern California are devising means of improving magnetic resonance (MR) techniques in order to enable application of these powerful characterization tools to study the structure and dynamics of biological molecules down to the level of single molecules. Dr. Takahashi is also developing educational/training programs and materials that will help explain these methods and the chemistry they help to explain to USC graduate and undergraduate students, as well as to high school and elementary school students in USC's neighborhood community.Magnetic resonance spectrometry techniques, such as nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), can provide detailed information about molecular structure and dynamics, but are hampered by intrinsically low sensitivity. Recent technological advances, particularly those utilizing a single nitrogen-vacancy (NV) center in diamond as a sensor, have enabled detection of a single electron spin. Dr. Takahashi seeks to demonstrate MR analysis of a few molecules under physiological conditions using NV centers and high-frequency/high-field EPR. Success in the research work will provide a promising pathway to enable EPR investigation of single biological molecules containing either native electron spin centers or extrinsic spin labels.

在化学测量与成像（CMI）以及化学结构，动力学和机制的支持下，A（CSDM -A）计划在化学划分中，Susumu Takahashi博士及其在南加州大学的小组正在设计磁共振成果（MR）技术来改善这些强大的摩尔级工具的磁性技术来研究结构和动力学的分数。 Dr. Takahashi is also developing educational/training programs and materials that will help explain these methods and the chemistry they help to explain to USC graduate and undergraduate students, as well as to high school and elementary school students in USC's neighborhood community.Magnetic resonance spectrometry techniques, such as nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), can provide detailed information about molecular structure and dynamics, but are受本质上低灵敏度的阻碍。 最近的技术进步，尤其是那些利用钻石中的单个氮呈（NV）中心作为传感器的技术进步，已经可以检测到单个电子自旋。 高桥博士寻求使用NV中心和高频/高场EPR来证明在生理条件下的一些分子的MR分析。 研究工作中的成功将提供有希望的途径，以使EPR研究包含天然电子自旋中心或外部自旋标签的单个生物分子。

项目成果

DNP-NMR of surface hydrogen on silicon microparticles

硅微粒表面氢的 DNP-NMR

• DOI: 10.1016/j.ssnmr.2019.04.008
• 发表时间: 2019
• 期刊: Solid State Nuclear Magnetic Resonance
• 影响因子: 3.2
• 作者: Shimon, Daphna;van Schooten, Kipp J.;Paul, Subhradip;Peng, Zaili;Takahashi, Susumu;Köckenberger, Walter;Ramanathan, Chandrasekhar
• 通讯作者: Ramanathan, Chandrasekhar

Reduction of surface spin-induced electron spin relaxations in nanodiamonds

• DOI: 10.1063/5.0007599
• 发表时间: 2020-08
• 期刊: arXiv: Mesoscale and Nanoscale Physics
• 作者: Zaili Peng;Jax Dallas;Susumu Takahashi

Investigation of near-surface defects of nanodiamonds by high-frequency EPR and DFT calculation

• DOI: 10.1063/1.5085351
• 发表时间: 2019-04-07
• 期刊: JOURNAL OF CHEMICAL PHYSICS
• 影响因子: 4.4
• 作者: Peng, Z.;Biktagirov, T.;Takahashi, S.
• 通讯作者: Takahashi, S.

Investigation of Coherence Time of a Nitrogen-Vacancy Center in Diamond Created by a Low-Energy Nitrogen Implantation

• DOI: 10.1007/s00723-017-0885-x
• 发表时间: 2017-06-01
• 期刊: APPLIED MAGNETIC RESONANCE
• 影响因子: 1
• 作者: Abeywardana, Chathuranga;Peng, Zaili;Takahashi, Susumu
• 通讯作者: Takahashi, Susumu

Understanding the Linewidth of the ESR Spectrum Detected by a Single NV Center in Diamond

• DOI: 10.1021/acs.jpca.9b02445
• 发表时间: 2019-07-25
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY A
• 影响因子: 2.9
• 作者: Fortman, Benjamin;Takahashi, Susumu
• 通讯作者: Takahashi, Susumu