Study of Synthetic/Living Feedback Systems Enabled by Innovation in Shape-Memory Polymers

形状记忆聚合物创新支持的合成/活体反馈系统研究

基本信息

批准号：
1609523
负责人：
James Henderson
金额：
$ 36万
依托单位：
Syracuse University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1609523&HistoricalAwards=false
关键词：
Study Synthetic Living Feedback Systems

项目摘要

Non-TechnicalBiomaterials are often used to study cells and tissues. Some biomaterials are designed with specific properties, such as stiffness or surface shape, to study how cells and tissues respond to those properties. This first category of biomaterials is improving understanding of how cells and tissues work in health or disease and how cells and tissue respond when in contact with biomaterials, such as those used in medical devices. Other biomaterials are designed to be "smart", meaning that they can undergo changes in properties such as stiffness or surface shape in response to exposure to water, light, or other triggers. This second category of bio-materials is providing new tools for controlling cells and tissues in research or therapies. This project will create and study a new third category of biomaterials that combine the properties of the first two. These new biomaterials will not only have specific properties to which cells and tissues respond but will also be "smart" and capable of responding to the presence of the cells and tissues. By studying the back-and-forth interaction, with the material responding to the cells and tissues and vice versa, new understanding will be developed regarding how cells and tissues work and how materials can be used to control them. Society will further benefit from a yearly workshop that will train central high school teachers on "Making Smart Materials."Stimuli responsive biomaterials have been developed to assay or control biological systems, but the potential of these biomaterials may be largely untapped. The potentially transformative opportunity is that of integrating stimuli responsive biomaterials with biological systems to create hybrid feedback systems that can provide new insight into phenomena at the interface of synthetic/living material systems. The goal of the proposed research is to create new stimuli responsive shape-memory polymers and study them in innovative synthetic/living feedback systems. Three objectives will be pursued. First, to tune cytocompatible shape-memory polymers for photo-thermal stimulation. Second, to develop and understand enzyme-responsive shape-memory polymers. Third, to study synthetic/living feedback systems, both systems that are imaging-enabled and semiautonomous and systems that are material-enabled and fully autonomous. This work is designed to be transformative in two ways: it will lead to novel material designs; and it will enable discovery of new material phenomena. Society will benefit from both the development of the individuals involved and through new knowledge that promises to drive advanced in biomedical fields. In addition, a yearly 2-day workshop will train central New York STEM teachers on "Making Smart Materials."TechnicalStimuli responsive biomaterials have been developed to assay or control biological systems, but the potential of these biomaterials may be largely untapped. The potentially transformative opportunity is that of integrating stimuli responsive biomaterials with biological systems to create hybrid feedback systems that can provide new insight into phenomena at the interface of synthetic/living material systems. The goal of the proposed research is to create new stimuli responsive shape-memory polymers and study them in innovative synthetic/living feedback systems. Three objectives will be pursued. First, to tune cytocompatible shape-memory polymers for photo-thermal stimulation. Second, to develop and understand enzyme-responsive shape-memory polymers. Third, to study synthetic/living feedback systems, both systems that are imaging-enabled and semiautonomous and systems that are material-enabled and fully autonomous. This work is designed to be transformative in two ways: it will lead to novel material designs; and it will enable discovery of new material phenomena. Society will benefit from both the development of the individuals involved and through new knowledge that promises to drive advances in biomedical fields. In addition, a yearly 2-day workshop will train central New York STEM teachers on "Making Smart Materials."

非技术生物材料通常用于研究细胞和组织。一些生物材料被设计为具有特定的特性，例如硬度或表面形状，以研究细胞和组织如何对这些特性做出反应。第一类生物材料正在提高人们对细胞和组织在健康或疾病中如何工作以及细胞和组织在与生物材料（例如医疗设备中使用的生物材料）接触时如何反应的理解。其他生物材料被设计为“智能”，这意味着它们可以在暴露于水、光或其他触发因素时发生硬度或表面形状等特性的变化。第二类生物材料为研究或治疗中控制细胞和组织提供了新工具。该项目将创建并研究结合前两类生物材料特性的新的第三类生物材料。这些新的生物材料不仅具有细胞和组织响应的特定特性，而且还将是“智能的”并且能够响应细胞和组织的存在。通过研究材料对细胞和组织做出反应的来回相互作用，反之亦然，将产生关于细胞和组织如何工作以及如何使用材料来控制它们的新理解。社会将进一步受益于每年一度的研讨会，该研讨会将培训中央高中教师“制造智能材料”。刺激响应生物材料已被开发用于分析或控制生物系统，但这些生物材料的潜力可能在很大程度上尚未开发。潜在的变革机会是将刺激响应生物材料与生物系统相结合，创建混合反馈系统，该系统可以为合成/活性材料系统界面的现象提供新的见解。拟议研究的目标是创造新的刺激响应形状记忆聚合物，并在创新的合成/活反馈系统中研究它们。将追求三个目标。首先，调整细胞相容性形状记忆聚合物以进行光热刺激。其次，开发和了解酶响应形状记忆聚合物。第三，研究合成/活体反馈系统，包括成像驱动的半自主系统和材料驱动的完全自主系统。这项工作旨在通过两种方式实现变革：它将带来新颖的材料设计；它将有助于发现新的物质现象。社会将受益于相关个人的发展以及有望推动生物医学领域进步的新知识。此外，每年为期 2 天的研讨会将对纽约中心 STEM 教师进行“制造智能材料”的培训。技术刺激响应生物材料已被开发用于分析或控制生物系统，但这些生物材料的潜力可能在很大程度上尚未开发。潜在的变革机会是将刺激响应生物材料与生物系统相结合，创建混合反馈系统，为合成/活性材料系统界面的现象提供新的见解。拟议研究的目标是创造新的刺激响应形状记忆聚合物，并在创新的合成/活反馈系统中研究它们。将追求三个目标。首先，调整细胞相容性形状记忆聚合物以进行光热刺激。其次，开发和了解酶响应形状记忆聚合物。第三，研究合成/活体反馈系统，包括成像驱动的半自主系统和材料驱动的完全自主系统。这项工作旨在通过两种方式实现变革：它将带来新颖的材料设计；它将有助于发现新的物质现象。社会将受益于相关个人的发展以及有望推动生物医学领域进步的新知识。此外，每年为期 2 天的研讨会将对纽约市中心的 STEM 教师进行“制作智能材料”的培训。