Development of Novel High Strength Biodegradable Metals for Temporary Biomedical Implants

开发用于临时生物医学植入物的新型高强度可生物降解金属

基本信息

批准号：
1607942
负责人：
Carl Boehlert
金额：
$ 31.7万
依托单位：
Michigan State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2023-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1607942&HistoricalAwards=false
关键词：
Development Novel Strength Biodegradable Metals

项目摘要

Non-Technical Abstract: A dream of the biomedical devices industry is to replace permanent endovascular stents with stents that can perform their function in the first few months and then dissolve in the host body, eliminating harmful long-term effects experienced with current permanent stents. This work seeks to overcome one of the most challenging aspects of biodegradable implant materials, controlling the microstructure, through processing, for enhancing the mechanical behavior and controlling the lifetime in physiological environments. The broader impacts of this work include use of the advanced thermomechanical processing methods to improve the mechanical properties of zinc-based biodegradable metals. This approach has the potential to change how biodegradable implants are processed and can initiate a revolution in the biomedical industry by implementing new processes for manufacturing biodegradable implants materials. Other broader impacts of the proposed work include producing modules on processing-microstructure-property relationships of zinc alloys, expanding an established K-12 hands-on SEM-based outreach program at Michigan State University (MSU), and providing research opportunities for graduate and undergraduate students. The modules and outreach program are intended to help promote K-12 students to enter Science, Technology, Engineering and Math (STEM) disciplines. Overall, this work is intended to make a lasting effect by understanding processing-microstructure-property relationships of zinc alloys.Technical Abstract:Because they exhibit near-ideal biocorrosion and biocompatibility behavior, zinc (Zn) and its alloys show promise for biomedical applications such as biodegradable stents. However, a primary drawback of pure Zn as an absorbable stent material is the lack of mechanical strength. The strengths of Zn alloys can be significantly improved through severe plastic deformation (SPD) techniques such as high-pressure torsion and equal channel angular pressing, both of which result in a significantly refined microstructure. The application of SPD techniques, such as these, is especially promising for metal matrix nanocomposites (MMNCs). Although MMNCs containing Zn as a matrix is in its infancy, they have the potential to result in biodegradable materials with enhanced strengths, while maintaining biocorrosion behavior and biocompatibility attractive for biodegradable implants. Overall, this program will evaluate the viability of Zn-matrix MMNCs as biodegradable implants and will test the novel SPD approach for grain refinement. A focus of this work will be to understand processing-microstructure-property relations of these materials. In addition, an understanding of the corrosion behavior and mechanisms and the nature of the biocompatibility of these materials in comparison to standard biodegradable Zn alloys will be obtained.

非技术摘要：生物医学设备行业的梦想是用可以在头几个月内执行其功能的支架代替永久的血管内支架，然后溶解在宿主体内，从而消除了当前永久支架所经历的有害长期效果。这项工作旨在克服可生物降解植入物材料的最具挑战性的方面之一，通过处理，加强机械行为并控制生理环境中的生命周期，控制微观结构。这项工作的更广泛的影响包括使用先进的热机械加工方法来改善基于锌的可生物降解金属的机械性能。这种方法有可能改变生物降解的植入物的处理方式，并通过实施新的生物降解植入物材料来实施生物医学行业的革命。拟议的工作的其他更广泛的影响包括生产有关锌合金处理 - 微生物 - 特性关系的模块，扩大了密歇根州立大学（MSU）的基于K-12动手的SEM外展计划，并为研究生和本科生提供研究机会。模块和外展计划旨在帮助促进K-12学生进入科学，技术，工程和数学（STEM）学科。总体而言，这项工作旨在通过理解锌合金处理 - 微生物 - 特性关系的关系来产生持久的效果。技术摘要：因为它们表现出近乎理想的生物腐蚀和生物相容性行为，因此锌（ZN）及其合金在生物医学应用中显示出有望的生物医学应用，例如可生物降解的可生物降解构成。但是，纯Zn作为可吸收支架材料的主要缺点是缺乏机械强度。通过严重的塑性变形（SPD）技术，例如高压扭转和相等的河道角压力，可以显着提高Zn合金的优势，这两者都会导致显着完善的微结构。对于金属基质纳米复合材料（MMNC），SPD技术的应用特别有望。尽管含有Zn作为基质的MMNC处于起步阶段，但它们有可能导致具有增强强度的可生物降解材料，同时保持生物腐蚀行为和对可生物降解植入物吸引的生物腐蚀行为和生物相容性。总体而言，该程序将评估Zn-Matrix MMNC作为可生物降解植入物的生存能力，并将测试新型的SPD方法进行谷物细化。这项工作的重点是了解这些材料的处理 - 微观结构关系。此外，将获得与标准可生物降解的Zn合金相比，了解这些材料的腐蚀行为和机制以及生物相容性的性质。