CSBR Living Stocks: Continued Support of the Duke Lemur Center for the Study of Primate Biology and History

CSBR 活畜：杜克狐猴灵长类生物学和历史研究中心的持续支持

• 批准号: 1561691
• 负责人: Anne Yoder
• 金额: $ 50万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1561691&HistoricalAwards=false
• 关键词: CSBR; Living; Stocks; Continued; Support

The Duke Lemur Center (DLC) is a unique institution dedicated to the study and care of the world's most endangered and biologically diverse primates: The lemurs of Madagascar. The DLC was founded on the principle that the study of lemurs and related primates can inform larger questions in biology such as the genetic and biological underpinnings of the human condition. Investigators and students from around the world come to Duke to study the living and fossil collections of the DLC. The DLC serves as a unique center for scientific inquiry, a hub for student activity, a nexus of knowledge, and a global partner for understanding and mitigating the Earth's escalating environmental challenges. Founded on the unifying themes of scientific inquiry, scholarship, information, and global engagement, the DLC will capitalize on recent revolutions in genomics, informatics and nanotechnology to make possible much more detailed investigation of its endangered primates and the application of these approaches for enhancing public knowledge of the scientific process. The DLC serves multiple educational communities, including the general public, K-12, undergraduate, graduate, and postgraduate students. A multitude of opportunities exist for engagement at the undergraduate and graduate student levels. In the past five years alone, more than 400 students from 98 institutions have engaged in research and/or training activities. Lemurs are endemic to the biodiversity hotspot of Madagascar, and due to their critically-endangered status, it would be impossible to recreate the taxonomic diversity of the DLC colony that presently contains 19 species. Over the past five-year period, 276 research projects led by 208 investigators from 100 institutions representing eight countries (primarily the U.S.) have been conducted at the DLC. These projects span a broad array of biological disciplines including, but not limited to, aging, behavioral ecology, biomechanics, cognition, epigenetics, life-history strategy, metabolomics, metagenomics, molecular evolution, neurophysiology, phylogeography, phylogenomics, population genetics, reproductive biology, sensory communication, speciation, and virology. During this three year project, the DLC will continue to make lemurs readily available to investigators, along with extensive collections of biological samples, decades of medical records, fossil representatives of extinct taxa, and rich life-history records. The DLC will also release a new version of the mouse lemur genome assembly, which will further enhance the research potential of the mouse lemur colony specifically, and the entire DLC colony by phylogenetic extension. In addition, the DLC will collaborate with Duke University's Center for In Vivo Microscopy, continue in vivo and ex vivo studies to produce an online multidimensional neural atlas of the dwarf and mouse lemurs. The DLC is also wholeheartedly committed to conservation activities via both ex situ captive management and in-country programs. The DLC's conservation Initiative in Madagascar has already served as a "landing pad" for numerous student and faculty researchers engaged in projects ranging from disease transmission, to behavioral ecology, to ecophysiology, to climate change. On-line access to colony inventories, demographics, metadata, research opportunities, and more is available through two web-based portals. Details on all facets of the DLC mission and activities can be found online (lemur.duke.edu).

公爵狐猴中心（DLC）是一个独特的机构，致力于研究和照顾世界上最濒危和生物学上多样的灵长类动物：马达加斯加的狐猴。 DLC的基础是基于以下原则：狐猴和相关灵长类动物的研究可以为生物学中的更大问题提供信息，例如人类状况的遗传和生物基础。 来自世界各地的调查人员和学生来杜克大学学习DLC的生活和化石收藏。 DLC是科学探究的独特中心，学生活动的枢纽，知识联系以及全球合作伙伴，以理解和减轻地球不断升级的环境挑战。 DLC建立在科学询问，奖学金，信息和全球参与的统一主题上，将利用最近在基因组学，信息学和纳米技术方面的革命，以使对其濒危灵长类动物的更详细研究以及这些方法的应用以及这些方法的应用，以增强公众的应用。了解科学过程。 DLC为包括公众，K-12，本科，研究生和研究生在内的多个教育社区提供服务。 在本科生和研究生级别上，存在许多机会。 仅在过去的五年中，来自98个机构的400多名学生从事研究和/或培训活动。 狐猴是马达加斯加的生物多样性热点的特有，由于其批判性地位，不可能重现目前包含19种种类的DLC殖民地的分类多样性。 在过去的五年中，由来自代表八个国家（主要是美国）的100个机构的208个调查人员领导的276个研究项目已在DLC进行。 These projects span a broad array of biological disciplines including, but not limited to, aging, behavioral ecology, biomechanics, cognition, epigenetics, life-history strategy, metabolomics, metagenomics, molecular evolution, neurophysiology, phylogeography, phylogenomics, population genetics, reproductive biology ，感官交流，物种形成和病毒学。 在这三年的项目中，DLC将继续使研究人员容易获得狐猴，以及大量的生物样品，数十年的医疗记录，灭绝分类单元的化石代表和丰富的生活历史记录。 DLC还将发布新版本的小鼠狐猴基因组组件，该组件将进一步增强小鼠狐猴菌落的研究潜力，并通过系统发育扩展来增强整个DLC菌落。此外，DLC将与杜克大学的体内显微镜中心合作，继续体内和实体研究，以生成矮人和小鼠狐猴的在线多维神经图集。 DLC还全心全意地致力于通过现场圈养管理和国内计划进行保护活动。 DLC在马达加斯加的保护计划已经为许多学生和教职员工研究人员曾是从事疾病传播，行为生态学，生态生理学再到气候变化等项目的“着陆垫”。 在线访问殖民地库存，人口统计，元数据，研究机会等，可以通过两个基于网络的门户网站获得。 DLC任务和活动的所有方面的详细信息都可以在线找到（lemur.duke.edu）。