EFRI 2-DARE: Functionalized Monolayer Heterostructures for Biosensors with Optical Readout

EFRI 2-DARE：用于具有光学读出功能的生物传感器的功能化单层异质结构

基本信息

批准号：
1542879
负责人：
Alan Johnson
金额：
$ 200万
依托单位：
University of Pennsylvania
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1542879&HistoricalAwards=false
关键词：
EFRI DARE Functionalized Monolayer Heterostructures

项目摘要

EFMA - 1542879PI: Johnson, Alan T.This project will develop new chemical sensors composed of biological molecules coupled to two-dimensional atomic crystals. The biological molecules will act as sensors by binding chemical targets in liquid and air samples. The atomic crystal layers will act as readouts by changing their optical or electronic properties when chemical targets are bound by the coupled biological molecules. The team will explore several biological molecules capable of binding specific targets coupled to various atomic crystals composed of compounds called transition metal dichalcogenides. The project will involve fabrication of the crystal layers, measurements of their electronic and optical properties, attachment of the biological molecules, and analysis of the resulting sensor capabilities. Experiments will be conducted in tandem with computational modeling to understand the response of the atomic crystals and predict sensor performance. Results of the project will lead to improved chemical sensors with unprecedented sensitivity and specificity for a variety of applications, including diagnosis of disease, environmental monitoring and law enforcement. The team will use the project to increase awareness of local communities about research at the frontier of nano-biotechnology and to involve student researchers, especially members of groups traditionally underrepresented in science and engineering. The goal of the project is to develop the basic scientific and engineering knowledge needed to advance nano-biosensor research towards implementation of transition metal dichalcogenides-based biosensors with optical and/or electronic readout. The team will develop scalable chemical vapor deposition approaches to large-area synthesis of MoS2, WS2, SnS2, and other materials identified through materials exploration. The material properties of these systems will be rigorously benchmarked using a combination of advanced structural, chemical, optical, electronic, and scanned probe measurements. A comprehensive set of chemical functionalization techniques will be developed suitable for fabrication of protein-functionalized biosensors with plasmonic, nanophotonic, and/or electronic readout. The impact of chemical functionalization on the electrical and optical properties will be systematically investigated. The measurements will be correlated with multi-scale computational models appropriate for simulating the response of the biosensors, with the goal of developing simulation methodologies suitable for predicting biosensor performance and guiding sensor design.

EFMA - 1542879PI：Johnson、Alan T。该项目将开发由与二维原子晶体耦合的生物分子组成的新型化学传感器。生物分子将通过结合液体和空气样本中的化学目标来充当传感器。当化学目标与耦合的生物分子结合时，原子晶体层将通过改变其光学或电子特性来充当读数器。该团队将探索几种能够结合特定靶标的生物分子，这些靶标与由过渡金属二硫化物组成的各种原子晶体耦合。该项目将涉及晶体层的制造、其电子和光学特性的测量、生物分子的附着以及由此产生的传感器功能的分析。实验将与计算模型同时进行，以了解原子晶体的响应并预测传感器性能。该项目的成果将改进化学传感器，使其具有前所未有的灵敏度和特异性，适用于疾病诊断、环境监测和执法等各种应用。该团队将利用该项目提高当地社区对纳米生物技术前沿研究的认识，并让学生研究人员，特别是传统上在科学和工程领域代表性不足的群体成员参与进来。该项目的目标是开发推进纳米生物传感器研究所需的基础科学和工程知识，以实现具有光学和/或电子读出功能的基于过渡金属二硫化物的生物传感器。该团队将开发可扩展的化学气相沉积方法，用于大面积合成 MoS2、WS2、SnS2 和通过材料探索确定的其他材料。这些系统的材料特性将结合先进的结构、化学、光学、电子和扫描探针测量进行严格的基准测试。将开发一套全面的化学功能化技术，适用于制造具有等离子体、纳米光子和/或电子读数的蛋白质功能化生物传感器。将系统地研究化学功能化对电学和光学性质的影响。测量结果将与适合模拟生物传感器响应的多尺度计算模型相关联，目标是开发适合预测生物传感器性能和指导传感器设计的模拟方法。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Synthesis of Mo 4 VAlC 4 MAX Phase and Two-Dimensional Mo 4 VC 4 MXene with Five Atomic Layers of Transition Metals

Mo 4 VAlC 4 MAX 相和五层过渡金属二维Mo 4 VC 4 MXene的合成

DOI：
10.1021/acsnano.9b07708
发表时间：
2020-01
期刊：
ACS Nano
影响因子：
17.1
作者：
Deysher, Grayson;Shuck, Christopher Eugene;Hantanasirisakul, Kanit;Frey, Nathan C.;Foucher, Alexandre C.;Maleski, Kathleen;Sarycheva, Asia;Shenoy, Vivek B.;Stach, Eric A.;Anasori, Babak;et al
通讯作者：
et al

Controlled Growth of Large-Area Bilayer Tungsten Diselenides with Lateral P–N Junctions

具有横向 P-N 结的大面积双层二硒化钨的受控生长

DOI：
10.1021/acsnano.9b04453
发表时间：
2019-08
期刊：
ACS Nano
影响因子：
17.1
作者：
Mandyam, Srinivas V.;Zhao, Meng;Masih Das, Paul;Zhang, Qicheng;Price, Christopher C.;Gao, Zhaoli;Shenoy, Vivek B.;Drndić, Marija;Johnson, Alan T.
通讯作者：
Johnson, Alan T.

Interfacial Electromechanics Predicts Phase Behavior of 2D Hybrid Halide Perovskites

界面机电预测二维混合卤化物钙钛矿的相行为

DOI：
10.1021/acsnano.9b09105
发表时间：
2020-03
期刊：
ACS Nano
影响因子：
17.1
作者：
Price, Christopher C.;Blancon, Jean;Mohite, Aditya D.;Shenoy, Vivek B.
通讯作者：
Shenoy, Vivek B.

Engineering Magnetic Phases in Two-Dimensional Non-van der Waals Transition-Metal Oxides

二维非范德华过渡金属氧化物中的工程磁相

DOI：
10.1021/acs.nanolett.9b02801
发表时间：
2019-09
期刊：
Nano Letters
影响因子：
10.8
作者：
Bandyopadhyay, Arkamita;Frey, Nathan C.;Jariwala, Deep;Shenoy, Vivek B.
通讯作者：
Shenoy, Vivek B.

Distinguishing electronic contributions of surface and sub-surface transition metal atoms in Ti-based MXenes

区分钛基 MXene 中表面和次表面过渡金属原子的电子贡献

DOI：
10.1088/2053-1583/ab68e7
发表时间：
2020-02-05
期刊：
2D Materials
影响因子：
5.5
作者：
Yizhou Yang;Kanit Hantanasirisakul;Nathan C Frey;B. Anasori;R. Green;P. Rogge;I. Waluyo;A. Hunt;P. Shafer;E. Arenholz;V. Shenoy;Y. Gogotsi;S. May
通讯作者：
S. May