CONFERENCE: Cold Spring Harbor Laboratory Synthetic Biology Course-July 27-August 10, 2015

会议：冷泉港实验室合成生物学课程-2015年7月27日至8月10日

• 批准号: 1539395
• 负责人: David Stewart
• 金额: $ 9.99万
• 依托单位: Cold Spring Harbor Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1539395&HistoricalAwards=false
• 关键词: CONFERENCE; Cold; Spring; Harbor; Laboratory

Synthetic biology is a rapidly expanding multi-disciplinary research area that relies on the integration of expertise in biology, engineering, mathematics, chemistry, and physics. This field uses theoretical and engineering principles to advance fundamental biological understanding and develop bio-inspired products. The challenge of synthetic biology today is that interdisciplinary expertise is often minimal, whereas a basic comprehension of the various underlying fields is crucial to foster successful collaborations. This course (July 27 - August 10, 2015) offered through the Cold Spring Harbor summer course educational program represents a significant effort to address this need. The series of lectures include laboratory exposure to cutting edge advances in experimental and theoretical synthetic biology. The course is structured to motivate the participants to share their knowledge with colleagues at their home institutions, which may inspire more broadly a systems and synthetic biology course and curriculum development. This course will help advance an emerging interdisciplinary science that, in addition to providing insights into the complexity of biology, will also inspire innovations that can provide critical solutions for many current and impending societal needs. The course fulfills an important need for development of an interdisciplinary research workforce that is more aware of the opportunities that can be realized from interdisciplinary collaborations including effective communication between students and experts. The teaching material includes cutting edge training in such areas as the theory and use of CRISPR technology to alter the genome of complex biological systems; proficiency in cell-free transcription-translation (TX-TL) methods; rapid molecular cloning using the Golden Gate assembly method; and gaining fundamental understanding of computational biology using ordinary differential equations. In addition, the course will provide sessions to develop specific biosensors for metabolic engineering.

合成生物学是一个快速扩展的多学科研究领域，依赖于生物学、工程学、数学、化学和物理学专业知识的整合。该领域利用理论和工程原理来推进基本的生物学理解并开发仿生产品。当今合成生物学面临的挑战是，跨学科专业知识通常很少，而对各个基础领域的基本理解对于促进成功的合作至关重要。通过冷泉港暑期课程教育计划提供的本课程（2015 年 7 月 27 日至 8 月 10 日）代表了满足这一需求的重大努力。该系列讲座包括实验室接触实验和理论合成生物学的前沿进展。该课程的结构是为了激励参与者与所在机构的同事分享他们的知识，这可能会更广泛地激发系统和合成生物学课程和课程开发。本课程将有助于推进新兴的跨学科科学，除了提供对生物学复杂性的见解之外，还将激发创新，为许多当前和即将到来的社会需求提供关键解决方案。该课程满足了跨学科研究队伍发展的重要需求，他们更加意识到跨学科合作可以实现的机会，包括学生和专家之间的有效沟通。教材包括 CRISPR 技术改变复杂生物系统基因组的理论和使用等领域的前沿培训；熟练掌握无细胞转录翻译（TX-TL）方法；使用金门组装方法进行快速分子克隆；并使用常微分方程获得对计算生物学的基本了解。此外，该课程还将提供开发代谢工程特定生物传感器的课程。