2015 Molecular Mechanisms in Evolution Gordon Research Conference held 28 Jun - 3 Jul 2015 at Stonehill College, Easton MA.

2015年进化分子机制戈登研究会议于2015年6月28日至7月3日在马萨诸塞州伊斯顿斯通希尔学院举行。

• 批准号: 1540359
• 负责人: Christine Queitsch
• 金额: $ 2.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1540359&HistoricalAwards=false
• 关键词: 2015; Molecular; Mechanisms; Evolution; Gordon

Quantitative approaches such as mathematical modeling, high-throughput phenotyping combined with technology development may yet yield a united theory of biology and life. The "modern synthesis" of the early twentieth century predated the molecular biology revolution and the genomics era. Although many of the assumptions and predictions of traditional population genetics have proven correct, others have to be modified due to new discoveries such as non-genetic, protein and RNA-based inheritance and stress-inducible mutations. Likewise, researchers in the fields of molecular biology, genomics, and medicine are often unacquainted with population genetics theory. This meeting is aimed at the growing numbers of investigators attempting to unite these formerly disparate fields and to learn from physicists how to arrive at universal principles. This meeting aims to provide a home and community for researchers involved in this ongoing, cross-disciplinary endeavor. The Gordon Research Conference (GRC) program includes invited and contributed oral and poster presentations by both younger and more established researchers, focusing on the best emerging science in the field.The second meeting of the new Gordon Research Conference Molecular Mechanisms in Evolution, June 28th-July 3rd, 2015 at Stonehill College, Easton, MA breaks new ground by focusing on the mechanistic understanding of how genetic and epigenetic variation arises, especially in response to environmental stress, and to which extent this variation generates phenotypic diversity, shapes evolution, and contributes to disease. The meeting sessions address a wide range of topics, including discussions of the constraints that cell biology and stochasticity pose for non-traditional mechanisms of inheritance, insights garnered from experiments in the laboratory, mechanisms of coding and regulation highlighting the unexpected plasticity of genomes. The meeting will discuss how mechanistic knowledge could be used to predict and arrest inheritance processes in infectious diseases and cancer. The GRC will promote international and national collaboration between physicists and biologists of diverse disciplines to promote systematic and quantitative analyses of biological processes, intensified theory building and deeper understanding of basic biology. This meeting will provide networking opportunities, inspiration and connections for young scientists, mentoring, and perspectives on cutting-edge new research for young participants at a critical stage in their careers. The requested funds will be used to defray the costs of a diverse group of graduate students, postdocs, new investigators, women, and minority participants.This project is being jointly supported by the Physics of Living Systems program in the Division of Physics and the Genetic Mechanisms Program in the Division of Molecular and Cellular Biosciences.

数学建模，高通量表型与技术发展相结合的定量方法可能会产生联合的生物学和生命理论。 20世纪初期的“现代综合”早于分子生物学革命和基因组学时代。尽管传统人口遗传学的许多假设和预测已被证明是正确的，但由于新发现，例如非遗传，蛋白质和基于RNA的遗传和应激诱导突变，因此必须修改其他假设和预测。同样，分子生物学，基因组学和医学领域的研究人员通常不熟悉种群遗传学理论。这次会议的目的是越来越多的调查人员试图团结这些以前的不同领域，并向物理学家学习如何达到普遍原则。这次会议旨在为参与这项正在进行的跨学科努力的研究人员提供家庭和社区。戈登研究会议（GRC）计划包括年轻人和更具成熟的研究人员的邀请和贡献口头和海报演讲，重点关注该领域的最佳新兴科学。新的戈登研究会议在进化中的分子机制的第二次会议，6月28日至7月3日，3月3日，2015年3月3日，在2015年在斯通希尔学院（Easton），埃斯顿（Easton）的新机制，尤其是在新的基础上，遍历了新的基础，该基础是肯定的，肯定是在各种范围内，遍布新的基础。对环境压力的反应以及这种变化在多大程度上产生表型多样性，塑造进化并导致疾病。会议会议介绍了广泛的主题，包括讨论细胞生物学和随机性对遗传的非传统机制的构成，从实验室的实验中获得的洞察力，编码机制和调节突出了基因组意外的可塑性。会议将讨论如何使用机械知识来预测和阻止传染病和癌症中的遗传过程。 GRC将促进物理学家与各种学科生物学家之间的国际和国家合作，以促进对生物过程的系统和定量分析，加强理论的建设以及对基本生物学的更深入了解。这次会议将为年轻的科学家提供网络机会，灵感和联系，指导和对年轻参与者在职业生涯的关键阶段的新研究的观点。所请求的资金将用于支付一群不同的研究生，博士后，新研究人员，妇女和少数群体参与者的成本。该项目在物理学部和分子生物科学部的物理学和遗传机制计划中共同支持。