SBIR Phase I: Degradation-Deformation Relationships in Novel Controlled-Dissolution Magnesium Alloys

SBIR 第一阶段：新型控制溶解镁合金的降解-变形关系

• 批准号: 1520252
• 负责人: Hunter Henderson
• 金额: $ 15万
• 依托单位: Boneco, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1520252&HistoricalAwards=false
• 关键词: SBIR; Phase; Degradation; Deformation; Relationships

This Small Business Innovation Research (SBIR) Phase I project aims to prepare a novel biodegradable magnesium alloy containing alkaline earth metals for commercialization by developing structure-property relationships between microstructure, degradation behavior, and mechanical behavior. With mechanical properties close to that of a traditional metal and the bioabsorbability of a polymer, magnesium has the potential to outcompete both classes of material as an orthopedic implant. These magnesium alloys can offer benefits to patients across a wide range of applications in the $50 billion implant market, and are particularly well suited to compete in the $500 million suture anchor market. Beyond advancing a particular alloy forward towards commercialization, this Phase I will result in a new understanding of how microstructure impacts degradation and mechanical properties, adding crucial data to the fledgling field of magnesium implants. In the near future, these medical devices will offer improved outcomes to patients, while becoming a dominant force in the implant market. The intellectual merit of this project is derived from the development of structure-property relationships between microstructure and both degradation and mechanical behavior. Sufficient mechanical integrity and an appropriate degradation rate are critical to the success of bioabsorbable mechanical implant, and these relationships must be established prior to broad in-vivo testing. The studies will consist of a suite of microstructural modification, in-vitro degradation testing, and bulk mechanical testing. The critical factors being considered are grain size, texture, precipitate morphology and volume fraction, degradation testing, compression, and tension testing. Once relationships between these variables are known, implants can be designed with optimized, and even tailored, properties for a given patient.

这项小型企业创新研究（SBIR）I期项目旨在准备一种新型的可生物降解镁合金，其中含有碱性地球金属，以通过在微结构，降解行为和机械行为之间发展结构 - 繁星限制。 具有接近传统金属的机械性能和聚合物的生物可吸收性，镁具有远离两类材料作为骨科植入物的潜力。 这些镁合金可以在500亿美元植入物市场的广泛应用中为患者提供好处，并且特别适合在5亿美元的缝合锚市市场上竞争。 除了促进特定合金向商业化方向前进外，这一阶段还将对微观结构如何影响降解和机械性能有了新的了解，从而为镁植入物的刚起步田地增加了关键数据。在不久的将来，这些医疗设备将为患者带来改善的预后，同时成为植入物市场的主要力量。该项目的智力优点源自微观结构与降解和机械行为之间的结构 - 培训关系的发展。足够的机械完整性和适当的降解速率对于可生物吸收的机械植入物的成功至关重要，并且必须在广泛的体内测试之前建立这些关系。研究将包括一套微结构修饰，体外降解测试和批量机械测试。所考虑的关键因素是晶粒尺寸，纹理，沉淀形态和体积分数，降解测试，压缩和张力测试。一旦已知这些变量之间的关系，就可以针对给定患者设计植入物，甚至针对给定患者进行优化甚至量身定制的特性。