RUI: Probing Molecular Recognition Profiles via Quasiracemic Materials

RUI：通过准外消旋材料探测分子识别概况

• 批准号: 1505717
• 负责人: Kraig Wheeler
• 金额: $ 29万
• 依托单位: Eastern Illinois University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1505717&HistoricalAwards=false
• 关键词: RUI; Probing; Molecular; Recognition; Profiles

Non-technical AbstractWith the support of the Solid State and Materials Chemistry program in the Division of Materials Research, this project explores how molecular shape impacts the internal organization of crystalline solids. Because material properties intimately relate to the composition of the building-blocks and their alignment, a greater understanding of the factors that influence component interactions holds much importance to the development of advanced materials that exhibit a wide-variety of functional properties. The project is anchored by a research team at Eastern Illinois University and will prove useful for probing the structural boundaries of the recognition process by investigating the complementary shapes of molecular neighbors. The educational and service component of the activity focuses on training students (undergraduate and Master's level) as scientists for careers in STEM fields, developing teaching modules for the introductory organic laboratory, and providing X-ray instrument services to the greater academic community of small colleges and universities that support rigorous undergraduate research programs.Technical AbstractMany functions of solid materials require exquisite control over the molecular architectures of their building blocks. The construction of structurally controlled supramolecular assemblies (e.g., bulk solids) is still at a primitive level despite great progress in the chemical synthesis of discrete molecules over the past few decades. This project explores the structural boundaries of molecular shape to the molecular recognition process by using the quasiracemate approach for constructing bimolecular compounds. Chiral building blocks formulated from known organic precursors will be synthesized via diarylamide and Pemoline templates. Since it is well known that a high propensity exists for organic molecules to arrange in centrosymmetric relationships, this activity explores the supramolecular behavior of these molecules to form quasicentrosymmetrically related aggregates. Video-supported thermomicroscopy and calorimetric techniques will be used to investigate the ability of pairs of materials to assemble. X-ray diffraction techniques will help determine the detailed structures of the materials obtained and assist with determining the topological contributions to these molecular assemblies.

非技术摘要在材料研究部固体与材料化学项目的支持下，该项目探讨了分子形状如何影响晶体固体的内部组织。 由于材料特性与构件的组成及其排列密切相关，因此更好地了解影响组件相互作用的因素对于开发具有多种功能特性的先进材料非常重要。 该项目由东伊利诺伊大学的一个研究小组主持，通过研究分子邻居的互补形状，将证明对于探测识别过程的结构边界很有用。 该活动的教育和服务部分侧重于将学生（本科生和硕士水平）培养为 STEM 领域的科学家，为入门有机实验室开发教学模块，并为小型学院的更大学术界提供 X 射线仪器服务以及支持严格的本科研究项目的大学。技术摘要固体材料的许多功能都需要对其构建单元的分子结构进行精确控制。 尽管过去几十年来离散分子的化学合成取得了巨大进展，但结构控制的超分子组装体（例如块状固体）的构建仍处于原始水平。 该项目通过使用准外消旋体方法构建双分子化合物，探索分子形状与分子识别过程的结构边界。 由已知有机前体配制的手性结构单元将通过二芳基酰胺和匹莫林模板合成。 由于众所周知，有机分子存在以中心对称关系排列的高度倾向，因此该活动探索了这些分子形成准中心对称相关聚集体的超分子行为。 视频支持的热显微镜和量热技术将用于研究成对材料的组装能力。 X 射线衍射技术将有助于确定所获得材料的详细结构，并有助于确定对这些分子组装体的拓扑贡献。