Spectroscopic Probes of Molecular Structure and Dynamics

分子结构和动力学的光谱探针

• 批准号: 1464957
• 负责人: Patrick Vaccaro
• 金额: $ 54.55万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464957&HistoricalAwards=false
• 关键词: Spectroscopic; Probes; Molecular; Structure; Dynamics

With this award, the Chemical Structure, Dynamics and Mechanisms (CSDM-A) Program of the Division of Chemistry is funding Professor Patrick Vaccaro of Yale University to investigate subtle effects in the way molecules interact with light and with other molecules. One of the two thrusts in the work supported by this award looks at the way light interacts with molecules with "handedness" -- for example, many molecules, especially biologically important molecules have non-superimposable mirror images, which is one kind of "handedness." The spectroscopic methods being developed in the Vaccaro laboratory aim to discriminate between different handed isomers of these molecules, as well as providing accurate benchmarks for theorists interested in modelling this phenomena. In the other thrust, the work will look at weakly interacting molecules in order to improve our understanding of the very subtle forces that molecules feel for each other. Professor Vaccaro's research students will be trained in optical and vacuum science as well as instrument design and construction. In an outreach project supported by this award, Professor Vaccaro and his students will work with students and teachers in the New Haven Public Schools. The Vaccaro research group is diverse, and has historically had a large number of female scientists. Professor Patrick Vaccaro and his research group will study an interesting set of spectroscopic systems. In one set of experiments, Vaccaro and his group will extend their past work on the chiroptical spectroscopy of isolated molecules in the gas phase. In the next phase of this work, the Vaccaro group will use cavity ringdown polarimetry to probe the electronic circular dichroism and electronic circular dichroism of some fairly complex chiral molecules in the gas phase, including molecules like (R) - norbornenone and the very weakly optically active species cyclopropane-1,2-d2. This work benefits from the collaboration with a number of prominent theoretical groups. New chiroptical investigations will look at chiral solutes dissolved in a rare-gas matrix. These later studies hope to investigate the changes in chiroptical response for molecules in weakly perturbing solvents. In a separate thrust, the Vaccaro group will investigate the weak interactions between aromatic molecules by studying benzene-tropolone dimers with a variety of spectroscopic methods, including two-color resonant four-wave mixing spectroscopy.

凭借该奖项，化学系的化学结构、动力学和机理 (CSDM-A) 项目正在资助耶鲁大学的帕特里克·瓦卡罗 (Patrick Vaccaro) 教授研究分子与光和其他分子相互作用方式的微妙影响。 该奖项支持的工作的两个主旨之一着眼于光与具有“旋手性”的分子相互作用的方式——例如，许多分子，尤其是生物学上重要的分子具有不可叠加的镜像，这是一种“旋手性” ”。 瓦卡罗实验室正在开发的光谱方法旨在区分这些分子的不同旋向异构体，并为有兴趣模拟这种现象的理论家提供准确的基准。 另一方面，这项工作将着眼于弱相互作用的分子，以提高我们对分子彼此感受到的非常微妙的力的理解。 瓦卡罗教授的研究生将接受光学和真空科学以及仪器设计和建造方面的培训。 在该奖项支持的推广项目中，瓦卡罗教授和他的学生将与纽黑文公立学校的学生和教师合作。瓦卡罗研究小组多元化，历史上曾有大量女性科学家。帕特里克·瓦卡罗教授和他的研究小组将研究一组有趣的光谱系统。 在一组实验中，瓦卡罗和他的团队将扩展他们过去在气相中孤立分子的手性光谱方面的工作。 在这项工作的下一阶段，Vaccaro小组将使用腔衰荡偏振法来探测气相中一些相当复杂的手性分子的电子圆二色性和电子圆二色性，包括像(R)-降冰片烯酮这样的分子和非常弱光学性质的分子。活性物质环丙烷-1,2-d2。 这项工作得益于与许多著名理论团体的合作。 新的手性光学研究将着眼于溶解在稀有气体基质中的手性溶质。 这些后来的研究希望研究弱扰动溶剂中分子手性光学响应的​​变化。 在另一个单独的项目中，瓦卡罗小组将通过使用各种光谱方法（包括双色共振四波混合光谱）研究苯托酚酮二聚体，研究芳香族分子之间的弱相互作用。