CAREER: Biofluid Dynamics of the Human Breast: Characterization and Fluid-Structure Interaction

职业：人类乳房的生物流体动力学：表征和流固相互作用

基本信息

批准号：
1454334
负责人：
Fatemeh Hassanipour
金额：
$ 50.32万
依托单位：
University of Texas at Dallas
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1454334&HistoricalAwards=false
关键词：
CAREER Biofluid Dynamics Human Breast

项目摘要

1454334HassanipourThe goal of this CAREER proposal is to study lactation in the human breast from a fluid dynamics point of view, considering the flow of milk as flow through a porous medium with flexible structure. Despite the scientific importance and impact on public health, bio-transport processes in the human breast have not been comprehensively studied, and are currently not well-understood. This is the white space that the current proposal aims to cover, with potential impact on the lives of millions of people. Success of the project can enable biomedical devise design and diagnosis of health conditions related to the female breast. This project has the potential for high rewards, since it can open up a completely new area of research. The societal and economic impact of understanding fundamentally the fluid-structure interaction in the human breast can be very significant, ranging from effective drug delivery to health condition diagnosis and the design of medical devises resolving lactation difficulties. The PI is proposing to use state-of-the-art experiments and simulations to understand the bio-transport behavior of the ductal system of the human breast. Advanced imaging and 3D printing techniques are going to be used to obtain realistic images of the pore structure within human breasts and then to manufacture prototypes for laboratory and computational investigation of the flow. The breast-infant interaction and the boundary effects of infant suckling will also be investigated. The proposed research activities are further integrated with an educational component including course development, and K-12 outreach activities that are a continuation of PI's past work with high-school students.

1454334Hassanipour 这项职业提案的目标是从流体动力学的角度研究人类乳房的哺乳，将乳汁的流动视为流经具有柔性结构的多孔介质。尽管对公共健康具有科学重要性和影响，但人类乳房中的生物转运过程尚未得到全面研究，目前还没有得到很好的理解。这是当前提案旨在涵盖的空白区域，对数百万人的生活具有潜在影响。该项目的成功可以实现与女性乳房相关的健康状况的生物医学设备设计和诊断。该项目具有获得高回报的潜力，因为它可以开辟一个全新的研究领域。从根本上了解人类乳房中的流体-结构相互作用的社会和经济影响可能非常重大，从有效的药物输送到健康状况诊断以及解决哺乳困难的医疗设备的设计。 PI 提议使用最先进的实验和模拟来了解人类乳房导管系统的生物运输行为。先进的成像和 3D 打印技术将用于获取人类乳房内孔隙结构的真实图像，然后制造用于实验室和流动计算研究的原型。还将研究母乳与婴儿的相互作用以及婴儿哺乳的边界效应。拟议的研究活动进一步与教育部分相结合，包括课程开发和 K-12 外展活动，这些活动是 PI 过去与高中生合作的延续。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Clinical Experiment on Infant Applied Pressures During Breastfeeding

母乳喂养期间婴儿施加压力的临床实验

DOI：
10.1115/imece2018-87674
发表时间：
2018-11
期刊：
ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers
影响因子：
0
作者：
Jiang, Lin;Alatalo, Diana L.;Geddes, Donna T.;Hassanipour, Fatemeh
通讯作者：
Hassanipour, Fatemeh

A mathematical modeling toolbox for ion channels and transporters across cell membranes

跨细胞膜离子通道和转运蛋白的数学建模工具箱