Neuronal coding of communication sounds in the central nucleus of the mouse auditory midbrain (inferior colliculus): time-domain analyses

小鼠听觉中脑（下丘）中央核通讯声音的神经元编码：时域分析

• 批准号: 217914967
• 负责人: Professor Dr. Günter Ehret
• 金额: --
• 依托单位: Institut für Neurobiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/217914967?language=en
• 关键词: Neuronal; coding; communication; sounds; central

Coding of streams of acoustic objects such as series of communication calls of animals or syllables and words in human speech is the “daily business” of mammalian auditory systems. Psychoacoustical and physiological experiments in humans have shown transitions in the perception of acoustic objects and auditory streams that occur with time constants near 20, 100, and 400 ms. These values in the time domain at which perceived sounds change their auditory quality have been found also in behavioral studies of house mice when they perceive and respond to their own communication calls. Thus, the mouse is an adequate animal model to test whether these time constants occur as general time windows of perceptual transition already at the subcortical level of sound processing, of which we know very little with regard to coding of auditory objects and streams. Hence, the present electrophysiological experiments were designed to analyze the main nucleus of the auditory midbrain (central nucleus of the inferior colliculus) with regard to coding the perceptually relevant time constants at the single neuron level and at the global level. Results are expected about the contribution of neuronal responses in the auditory midbrain to auditory object formation in the time domain and the coding of rhythms (streams of auditory objects). Such data are new and of general importance since they directly relate neuronal processing and coding in the midbrain to common properties of mammalian auditory perception.

对声学对象流（例如动物的一系列通信呼叫或人类语音中的音节和单词）进行编码是哺乳动物听觉系统的“日常工作”。人类的心理声学和生理实验表明，声学对象和听觉流的感知发生了转变。时间常数接近 20、100 和 400 毫秒时发生的这些值在时域中感知到的声音会改变它们的听觉质量，这也在家鼠感知和响应时的行为研究中被发现。因此，小鼠是一个足够的动物模型来测试这些时间常数是否作为感知转换的一般时间窗口出现在声音处理的皮层下水平，而我们对听觉编码知之甚少。因此，本电生理学实验旨在分析听觉中脑的主要核（下丘的中央核），以编码单个神经元水平和全局水平的感知相关时间常数。预计关于听觉中脑中的神经反应对时域听觉对象形成和节奏编码（听觉对象流）的贡献，这些数据是新的并且具有普遍重要性，因为它们直接将中脑中的神经处理和编码与听觉对象形成相关。哺乳动物听觉感知的共同特性。