Neuronal coding of communication sounds in the central nucleus of the mouse auditory midbrain (inferior colliculus): time-domain analyses

小鼠听觉中脑（下丘）中央核通讯声音的神经元编码：时域分析

• 批准号: 217914967
• 负责人: Professor Dr. Günter Ehret
• 金额: --
• 依托单位: Institut für Neurobiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/217914967?language=en
• 关键词: Neuronal; coding; communication; sounds; central

Coding of streams of acoustic objects such as series of communication calls of animals or syllables and words in human speech is the “daily business” of mammalian auditory systems. Psychoacoustical and physiological experiments in humans have shown transitions in the perception of acoustic objects and auditory streams that occur with time constants near 20, 100, and 400 ms. These values in the time domain at which perceived sounds change their auditory quality have been found also in behavioral studies of house mice when they perceive and respond to their own communication calls. Thus, the mouse is an adequate animal model to test whether these time constants occur as general time windows of perceptual transition already at the subcortical level of sound processing, of which we know very little with regard to coding of auditory objects and streams. Hence, the present electrophysiological experiments were designed to analyze the main nucleus of the auditory midbrain (central nucleus of the inferior colliculus) with regard to coding the perceptually relevant time constants at the single neuron level and at the global level. Results are expected about the contribution of neuronal responses in the auditory midbrain to auditory object formation in the time domain and the coding of rhythms (streams of auditory objects). Such data are new and of general importance since they directly relate neuronal processing and coding in the midbrain to common properties of mammalian auditory perception.

哺乳动物听觉系统的“日常业务”，诸如动物或音节的一系列通信呼叫等声学对象的编码。人类的心理和物理实验表明，随着时间常数在20、100和400毫秒接近的时间常数发生的声学和听觉流的感知中。这些价值观在感知声音的时间域中会改变其听觉质量的时间域，在房屋小鼠的行为研究中也发现了他们的感觉并响应自己的通信呼叫。这是鼠标是一个足够的动物模型，可以测试这些时间常数是否出现在声音处理下的感知过渡的一般时间窗口中，我们在听觉对象和流的编码方面几乎不知道。因此，目前的电生理实验旨在分析听觉中脑的主要核核（下丘中心核心），以编码单个神经元和全球水平上的感知相关时间常数。预计听觉中脑中神经元反应对时间域中听觉对象形成的贡献和节奏的编码（听觉对象的流）。此类数据是新的，并且非常重要，因为它们将中脑的神经元处理和编码直接与哺乳动物听觉感知的共同特性相关。