CPS: Frontier: Collaborative Research: Compositional, Approximate, and Quantitative Reasoning for Medical Cyber-Physical Systems

CPS：前沿：协作研究：医疗网络物理系统的组合、近似和定量推理

• 批准号: 1446725
• 负责人: Frank Pfenning
• 金额: $ 19.61万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1446725&HistoricalAwards=false
• 关键词: CPS; Frontier; Collaborative; Research; Compositional

This project represents a cross-disciplinary collaborative research effort on developing rigorous, closed-loop approaches for designing, simulating, and verifying medical devices. The work will open fundamental new approaches for radically accelerating the pace of medical device innovation, especially in the sphere of cardiac-device design. Specific attention will be devoted to developing advanced formal methods-based approaches for analyzing controller designs for safety and effectiveness; and devising methods for expediting regulatory and other third-party reviews of device designs. The project team includes members with research backgrounds in computer science, electrical engineering, biophysics, and cardiology; the PIs will use a coordinated approach that balances theoretical, experimental and practical concerns to yield results that are intended to transform the practice of device design while also facilitating the translation of new cardiac therapies into practice.The proposed effort will lead to significant advances in the state of the art for system verification and cardiac therapies based on the use of formal methods and closed-loop control and verification. The animating vision for the work is to enable the development of a true in silico design methodology for medical devices that can be used to speed the development of new devices and to provide greater assurance that their behaviors match designers' intentions, and to pass regulatory muster more quickly so that they can be used on patients needing their care. The scientific work being proposed will serve this vision by providing mathematically robust techniques for analyzing and verifying the behavior of medical devices, for modeling and simulating heart dynamics, and for conducting closed-loop verification of proposed therapeutic approaches. The acceleration in medical device innovation achievable as a result of the proposed research will also have long-term and sustained societal benefits, as better diagnostic and therapeutic technologies enter into the practice of medicine more quickly. It will also yield a collection of tools and techniques that will be applicable in the design of other types of devices. Finally, it will contribute to the development of human resources and the further inclusion of under-represented groups via its extensive education and outreach programs, including intensive workshop experiences for undergraduates.

该项目代表了跨学科的合作研究工作，用于开发严格的，闭环的方法，用于设计，模拟和验证医疗设备。 这项工作将开辟基本的新方法，以从根本上加速医疗设备创新的速度，尤其是在心脏设备设计领域。具体的关注将致力于开发基于正式方法的高级方法，以分析控制器设计的安全性和有效性；并设计了加快设备设计监管和其他第三方评论的方法。 项目团队包括具有计算机科学，电气工程，生物物理学和心脏病学研究背景的成员； the PIs will use a coordinated approach that balances theoretical, experimental and practical concerns to yield results that are intended to transform the practice of device design while also facilitating the translation of new cardiac therapies into practice.The proposed effort will lead to significant advances in the state of the art for system verification and cardiac therapies based on the use of formal methods and closed-loop control and verification. 这项工作的动画愿景是为医疗设备的计算机设计方法的发展开发，可用于加快新设备的开发，并提供更大的保证，即它们的行为与设计师的意图相匹配，并更快地通过监管召集，以便可以将其用于需要护理的患者。 提出的科学工作将通过提供数学上强大的技术来分析和验证医疗设备的行为，建模和模拟心脏动力学以及对拟议治疗方法进行闭环验证。 由于拟议的研究，可以实现医疗设备创新的加速性也将具有长期和持续的社会利益，因为更好的诊断和治疗技术更快地进入医学实践。 它还将产生一系列工具和技术，这些工具和技术将适用于其他类型的设备的设计。 最后，它将通过其广泛的教育和外展计划，包括针对本科生的强化研讨会经验，为人力资源的发展以及进一步代表性的群体的进一步贡献。