WORKSHOP: Design, Engineering & Selection of Novel Proteins to be held in Arlington, VA; May 12-13, 2014.

研讨会：设计、工程

• 批准号: 1439222
• 负责人: Michael Hecht
• 金额: $ 4.96万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1439222&HistoricalAwards=false
• 关键词: WORKSHOP; Design; Engineering; & Selection

Approximately 20 leading scientists will attend this workshop to discuss the "state of the field" with respect to designing novel proteins and enzymes. These scientists represent a broad range of expertise: Some specialize in computational design of novel proteins, while others focus on evolutionary and combinatorial methods for selection and optimization. The purpose of the workshop will be threefold: (i) To describe how contributions from different disciplines have enabled enormous recent advances in our ability to devise novel proteins that fold and function; (ii) To discuss the potential for future developments in this field, and describe how cross-fertilization between disciplines can enhance this progress; and (iii) To explicitly discuss challenges and/or roadblocks that might impede this progress, and to propose approaches that will enable researchers to overcome these challenges in the coming decade. The workshop will focus on both basic science and real-world applications of protein design, engineering, and selection.

大约 20 名顶尖科学家将参加本次研讨会，讨论设计新型蛋白质和酶的“领域现状”。这些科学家代表了广泛的专业知识：一些专门从事新型蛋白质的计算设计，而另一些则专注于选择和优化的进化和组合方法。 研讨会的目的有三个：（i）描述不同学科的贡献如何使我们在设计可折叠和发挥功能的新型蛋白质的能力方面取得巨大进展； (ii) 讨论该领域未来发展的潜力，并描述学科之间的交叉融合如何促进这一进展； (iii) 明确讨论可能阻碍这一进展的挑战和/或障碍，并提出使研究人员能够在未来十年克服这些挑战的方法。该研讨会将重点关注蛋白质设计、工程和选择的基础科学和实际应用。