Conference: 2014 Intrinsically Disordered Proteins Gordon Research Conference and Gordon Research Seminar to be held on July 5-6, 2014 in Stonehill College Easton, MA

会议：2014 本质无序蛋白质戈登研究会议和戈登研究研讨会将于 2014 年 7 月 5 日至 6 日在马萨诸塞州伊斯顿斯通希尔学院举行

• 批准号: 1421003
• 负责人: Gary Daughdrill
• 金额: $ 0.6万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1421003&HistoricalAwards=false
• 关键词: Conference; 2014; Intrinsically; Disordered; Proteins

Intellectual Merit 2014 Gordon Research Conference on IDPs will expand our knowledge of the structure, dynamics, and function of IDPs, will provide insights into the diverse biological processes that involve IDPs, and will drive new discoveries on the molecular mechanisms of IDPs in cell biology, and will provide a unique opportunity for the training of graduate students, postdoctoral fellows, and early career investigators. There are a number of important challenges that must be met before we can develop a general picture of the dynamic structure, function, and evolution of IDPs/IDRs. Major challenges include developing new experimental and computational approaches to characterize structure and dynamics of IDPs/IDRs, understanding the expression patterns, molecular networks, and evolution of IDPs/IDRs and identifying fundamental principles of molecular recognition, regulation, folding, allostery, and mutational robustness for IDPs/IDRs. Speakers for the IDP GRC are directly addressing these challenges and making important contributions to developing solutions that will enhance our understanding of IDP structure, dynamics, function, and evolution. Addressing these challenges will have a profound impact on our understanding of (a) how IDPs/IDRs contribute to cellular function (b) how mutations in such regions can cause disease, and (c) how the distinct physico-chemical properties of IDPs/IDRs can be exploited for applications in various fields such as nanotechnology, material sciences and biotechnology. Broader ImpactsIn addition to advancing scientific knowledge in Molecular Biology, Structural Biology, Evolutionary Biology, Bioinformatics, Genetics, and Biophysics, the 2014 IDP GRC will provide a unique opportunity for the training of graduate students, postdoctoral fellows, and early career investigators. For the first time in the meeting series, a Gordon Research Seminar (GRS) will precede the main conference. The IDP GRS is designed to further facilitate the participation of graduate students, postdoctoral researchers, and early career investigators. Planned by and for the trainees, it will provide an opportunity for junior researchers to present seminars and posters in a supportive, interactive environment. It will act as an important springboard for the development of the future leaders in the field. The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. The focus of the IDP GRS is to introduce the topic of IDPs to those just entering the field while motivating interest in key areas of IDP research. Topics covered will include: (i) what characteristics define an IDP, (ii) what experimental and computational tools can be used to study IDPs, and (iii) what roles IDPs play in vivo. The GRS will also include a career development session featuring a panel of scientists at different points in their career path who will offer career advice and answer questions on the academic job search from a variety of perspectives. Every effort has been made to include women and members of underrepresented groups in the conference. The goal is to have attendance in this area in the range of 25-30%, which is the percentage of women and members of underrepresented groups that are members of the IDP subgroup at the Biophysical Society.

Intellectual Merit 2014 Gordon IDPs 研究会议将扩展我们对 IDPs 的结构、动力学和功能的了解，将提供对涉及 IDPs 的多种生物过程的见解，并将推动细胞生物学中 IDPs 分子机制的新发现，并将为研究生、博士后研究员和早期职业研究人员的培训提供独特的机会。在我们能够全面了解 IDP/IDR 的动态结构、功能和演变之前，必须解决许多重要的挑战。主要挑战包括开发新的实验和计算方法来表征 IDP/IDR 的结构和动态，了解 IDP/IDR 的表达模式、分子网络和进化，以及确定分子识别、调节、折叠、变构和突变鲁棒性的基本原理对于 IDP/IDR。 IDP GRC 的发言人正在直接应对这些挑战，并为开发解决方案做出重要贡献，这些解决方案将增强我们对 IDP 结构、动态、功能和演变的理解。解决这些挑战将对我们理解以下方面产生深远影响：(a) IDP/IDR 如何促进细胞功能；(b) 这些区域的突变如何导致疾病；(c) IDP/IDR 的独特物理化学特性如何可用于纳米技术、材料科学和生物技术等各个领域的应用。更广泛的影响除了推进分子生物学、结构生物学、进化生物学、生物信息学、遗传学和生物物理学方面的科学知识之外，2014 年 IDP GRC 还将为研究生、博士后研究员和早期职业研究人员的培训提供独特的机会。在该系列会议中，戈登研究研讨会 (GRS) 将首次在主会议之前举行。 IDP GRS 旨在进一步促进研究生、博士后研究人员和早期职业研究人员的参与。它由受训者计划并为受训者服务，将为初级研究人员提供在支持性互动环境中展示研讨会和海报的机会。它将成为该领域未来领导者发展的重要跳板。会议将包括大约 10 场演讲和 2 场墙报会议。所有与会者都应通过口头报告或展示海报的方式积极参与 GRS。 IDP GRS 的重点是向刚刚进入该领域的人介绍 IDP 主题，同时激发他们对 IDP 研究关键领域的兴趣。涵盖的主题包括：(i) IDP 的特征是什么，(ii) 可以使用哪些实验和计算工具来研究 IDP，以及 (iii) IDP 在体内发挥什么作用。 GRS 还将包括一次职业发展会议，由处于职业道路不同阶段的科学家组成的小组组成，他们将从不同的角度提供职业建议并回答有关学术求职的问题。我们已尽一切努力让妇女和代表性不足的群体成员参加会议。目标是使该领域的出席率在 25-30% 范围内，这是生物物理学会 IDP 小组成员中女性和代表性不足群体成员的百分比。