Responsive and Healable Materials Constructed via Dynamic-Covalent Bonds

通过动态共价键构建的响应和可修复材料

• 批准号: 1410223
• 负责人: Brent Sumerlin
• 金额: $ 22.6万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1410223&HistoricalAwards=false
• 关键词: Responsive; Healable; Materials; Constructed; via

NON-TECHNICAL SUMMARY: This project will test the hypothesis that dynamic interactions can be used to prepare materials that reversibly assemble and disassemble in solution or in the bulk state. Two specific classes of materials will be considered. The first system will involve nanosized polymeric assemblies that can be triggered to disassemble when high concentrations of sugar are in the surrounding solution. Provided these assemblies can be loaded with molecular cargo, such materials may prove useful for the sugar-induced release of insulin or other therapeutics. The second system to be investigated will consist of bulk plastic or elastomer-like materials capable of healing after being torn, scratched, or broken. Materials that self-heal may find utility in a variety of applications, including being used in medical devices, coatings, and elastomers. Both classes of materials to be studied will derive their adaptability and healability from the design and architectural structure introduced by the synthetic approach in this project. In addition to the development of new materials, studying their underlying chemical and physical properties, and considering the potential utility of these materials, this research will help to educate and train scientists at many levels in a field that is inherently multidisciplinary. TECHNICAL SUMMARY: This research plan is designed to exploit boronic/boronate ester reversibility within the field of responsive polymeric materials. The main hypothesis of the proposed research is that the dynamic-covalent nature of boronic/boronate ester crosslinks can be utilized to achieve stimuli-responsive and self-healing behaviors in two classes of materials. The first class of materials is composed of polymeric vesicles crosslinked via boronic esters. Block copolymers with one hydrophilic block and one boronic acid-containing block will be self-assembled and crosslinked with a multifunctional diol that can be induced to dissociate under high concentrations of sugars and other small molecule diols. The second class of materials to be investigated consists of bulk polymeric materials crosslinked via boronic esters. Upon material failure, healing can be induced by boronic ester exchange at the damage interface. While this phenomenon has been employed for small molecule organic synthesis, molecular recognition, and saccharide sensing, its incorporation in the fields of materials design and controlled polymer synthesis has been significantly limited. Materials that autonomously self-heal may find utility in a variety of applications, including being used in medical devices, coatings, and elastomers. Graduate students involved in this project will gain valuable insight into the emerging fields of reversible-covalent and self-healing materials. Outreach efforts will be a key component of this project and will involve exposure of area high school and community college students to research in these areas.

非技术摘要：该项目将检验以下假设：动态相互作用可用于制备可逆地组装和拆卸在解决方案或散装状态下的材料。将考虑两种特定类别的材料。第一个系统将涉及纳米化聚合物组件，当高浓度的糖在周围溶液中时，可以触发以拆卸。只要这些组件可以装有分子货物，这种材料可能被证明可用于糖引起的胰岛素或其他疗法的释放。要研究的第二个系统将包括散装塑料或类似弹性的材料，能够在被撕裂，刮擦或破裂后能够愈合。自我修饰的材料可能会在各种应用中找到效用，包括用于医疗设备，涂料和弹性体中。两类要研究的材料都将从该项目中的合成方法引入的设计和建筑结构中得出它们的适应性和可治愈性。除了开发新材料，研究其潜在的化学和物理特性，并考虑这些材料的潜在效用外，这项研究还将有助于在本质上具有多学科的领域中的许多层面教育和培训科学家。 技术摘要：该研究计划旨在利用响应式聚合物材料领域内的硼酸/硼酸酯可逆性。拟议的研究的主要假设是，可以利用硼酸/硼酸酯交联的动态共价性质来实现两类材料中的刺激反应性和自我修复行为。第一类材料由通过硼旋酯交联的聚合囊泡组成。具有一个亲水性块和一个含硼酸的块的嵌段共聚物将被自组装并与多功能二醇进行自组装和交联，可引起在高浓度的糖和其他小分子二醇下解离。要研究的第二类材料由通过硼烷酯交联的大量聚合物材料组成。材料故障后，可以通过损伤界面处的硼烯酯交换来诱导愈合。虽然该现象已用于小分子有机合成，分子识别和糖水感应，但其在材料设计和受控聚合物合成领域的掺入已受到显着限制。自主自我修复的材料可能会在各种应用中找到效用，包括用于医疗设备，涂料和弹性体。参与该项目的研究生将获得对可逆的共价和自我修复材料的新兴领域的宝贵见解。外展工作将是该项目的关键组成部分，并将涉及在这些地区进行研究。