STTR Phase I: A novel biomimetic nanofiber coating on dental implants for gingival regeneration

STTR 第一阶段：用于牙龈再生的牙种植体上的新型仿生纳米纤维涂层

• 批准号: 1346430
• 负责人: Qing Liu
• 金额: $ 22.5万
• 依托单位: 3D Biotek, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1346430&HistoricalAwards=false
• 关键词: STTR; Phase; novel; biomimetic; nanofiber

This Small Business Technology Transfer Research (STTR) Phase I project is seeking to develop a novel cost-effective strategy to modify dental implants with biomimetic nanofibers for controlled regeneration of gingival tissue. In order to seal the dental implants from bacteria and consequently protect the crestal bone from infection-induced deterioration, there is an unmet need to promote a prompt and effective attachment of gingival tissue onto the implant surface. The project proposes to coat aligned biomimetic nanofibers onto the collar of dental implants for rapid adhesion and controlled growth of gingival cells along the fibers. It is anticipated that an accelerated formation of new gingival connective tissue will take place right onto the biomimetic nanofibers, leading to a proper seal of dental implants from oral cavity. The same aligned nanofibers can be useful to modify other implant surfaces for guided accelerated tissue regeneration.The broader impact/commercial potential of this project is that the proposed cost-effective biomimetic nanofiber coating will provide a competitive solution to a common problem, i.e., infection-induced implant failure. This type of nano-fiber coated dental implants has a great potential to penetrate the rapidly growing dental implant market which is projected to be $8.1 billion by 2015. Teaming up with the leading industry partners will facilitate the commercialization of this novel technology upon completion of the proposed studies.

这个小型企业技术转移研究（STTR）第一阶段项目正在寻求开发一种新颖的、具有成本效益的策略，用仿生纳米纤维修改牙种植体，以控制牙龈组织的再生。为了密封牙种植体免受细菌侵害，从而保护牙槽嵴骨免受感染引起的恶化，促进牙龈组织迅速有效地附着到种植体表面上的需求尚未得到满足。该项目建议将对齐的仿生纳米纤维涂在牙种植体的颈圈上，以实现牙龈细胞沿着纤维的快速粘附和受控生长。预计新的牙龈结缔组织将在仿生纳米纤维上加速形成，从而实现牙种植体与口腔的正确密封。相同的排列纳米纤维可用于修改其他植入物表面，以引导加速组织再生。该项目更广泛的影响/商业潜力是，所提出的具有成本效益的仿生纳米纤维涂层将为常见问题（即感染）提供有竞争力的解决方案引起的种植体失败。这种类型的纳米纤维涂层牙种植体具有巨大的潜力，可以渗透到快速增长的牙种植体市场，预计到 2015 年该市场将达到 81 亿美元。与领先的行业合作伙伴合作，将在项目完成后促进这项新技术的商业化。拟议的研究。