I-Corps: Selenium Nucleic Acids for Structure Determination, Drug Discovery and Commercialization

I-Corps：用于结构测定、药物发现和商业化的硒核酸

• 批准号: 1340153
• 负责人: Zhen Huang
• 金额: $ 5万
• 依托单位: Georgia State University Research Foundation, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2014-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1340153&HistoricalAwards=false
• 关键词: Corps; Selenium; Nucleic; Acids; Structure

This project plans to develop and explore potential value of selenium nucleic acids in 3D structure studies and drug discovery of the longer nucleic acids and their protein complexes, especially drug target characterization. Nucleic acids and their protein complexes have been recognized as important drugs targets in cancer treatments. DNAs are frequent targets of many small-molecule drugs with anticancer activities. High-resolution structures of DNAs and their ligand complexes are critical in drug design, discovery, and mechanism study. X-ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes. Moreover, crystallography is one of the best strategies to provide structure information of these macromolecules with high resolutions. The research team is developing novel selenium strategies to increase structure resolutions of nucleic acids and their complexes with ligands (including proteins and small molecules) for drug target study and drug development. The overall goal of this proposal is to develop and commercialize the SeNA strategies for determining high-resolution crystal structures of nucleic acids and their complexes with small molecule drugs (or potential drugs) and protein complexes for disease study (such as cancer research) and drug development.Se-nucleic acid research will provide insights into nucleic acid chemistry and biochemistry, and the structural and functional properties, which are of great interest to scientific community as well as to the general public. Se-nucleic acids may lead to novel materials and applications. Furthermore, this proposed project will allow the widespread access to these valuable new materials. These potential discoveries could encourage their widespread use and allow broader access to these unique materials for function and structure studies.

该项目计划在3D结构研究中开发和探索核酸硒的潜在价值，并发现较长的核酸及其蛋白质复合物，尤其是药物靶标表征。核酸及其蛋白质复合物已被认为是癌症治疗中的重要药物靶标。 DNA是许多具有抗癌活性的小分子药物的常见靶标。 DNA及其配体复合物的高分辨率结构在药物设计，发现和机理研究中至关重要。 X射线晶体学是用于结构这些大分子和复合物的最直接，最有力的工具之一。此外，晶体学是提供具有高分辨率的这些大分子的结构信息的最佳策略之一。研究团队正在开发新型的硒策略，以增加核酸的结构分辨率及其与配体（包括蛋白质和小分子）的复合物进行药物靶向研究和药物开发。该提案的总体目标是开发和商业化塞纳策略，以确定核酸的高分辨率晶体结构及其与小分子药物（或潜在药物）（或潜在药物）和蛋白质复合物（例如癌症研究）和药物研究的蛋白质复合物（例如癌症研究）和蛋白质络合开发。Se-核酸研究将为核酸化学和生物化学以及结构和功能特性提供见解，这对科学界以及公众引起了极大的兴趣。核酸可能导致新颖的材料和应用。此外，这个建议的项目将允许广泛访问这些有价值的新材料。这些潜在的发现可以鼓励它们广泛使用，并可以更广泛地使用这些独特的材料进行功能和结构研究。