MRI: Acquisition of a Small Molecule Single Crystal X-ray Diffractometer for Research and Education Across Montana

MRI：购买小分子单晶 X 射线衍射仪，用于蒙大拿州的研究和教育

• 批准号: 1337908
• 负责人: Orion Berryman
• 金额: $ 26.5万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1337908&HistoricalAwards=false
• 关键词: MRI; Acquisition; Small; Molecule; Single

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Orion Berryman from the University of Montana and colleagues Tom Livingstone, Robert Szilagyi, Edward Rosenberg and Charles Thompson will acquire a single crystal X-ray diffractometer. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) development of organocatalysts with halogen bonding; (b) solid-state structures of luminescent ruthenium diimine complexes; (c) development of molecular yardsticks to determine the spatial dimensions and key binding motifs of glutamate transporter proteins; (d) asymmetric catalysis of Group 3 metals and cationic cyclizations; (e) development of structure activity relationships for isoxazole containing drug candidates; and (f) electronic and geometric structures of metalloenzymatic and organometallic catalysts.An X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research and research training and will contribute to educate students both at the University of Montana and Montana State University including those from a Native American background as well as high school students and those at a tribal college.

凭借由化学研究仪器和设施共同资助的主要研究仪器计划的奖项，蒙大拿大学和同事汤姆·利文斯通，罗伯特·塞勒基（Robert Szilagyi），爱德华·罗森伯格（Edward Rosenberg）和查尔斯·汤普森单晶X射线衍射仪。该提案旨在增强各个层次的研究和教育，尤其是在（a）具有卤素键合的有机催化剂等领域； （b）发光氟二胺复合物的固态结构； （c）开发分子码来确定谷氨酸转运蛋白的空间维度和关键结合基序； （d）3类金属和阳离子环化的不对称催化； （e）开发含有候选药物的异恶唑的结构活动关系； （f）金属酶和有机金属催化剂的电子和几何结构。X射线衍射仪可以准确，精确地测量分子的完整三维结构，包括键距离和角度，并提供有关有关空间安排的准确信息分子相对于相邻分子。此处描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。该乐器将是教学和研究和研究培训的组成部分，并将为蒙大拿大学和蒙大拿州立大学的学生提供教育，包括来自美国原住民背景的学生以及高中生和部落的学生大学。