Nanofibers from Multilayered Forced Assembly Polymer Films

来自多层强制组装聚合物薄膜的纳米纤维

• 批准号: 1335276
• 负责人: Gary Wnek
• 金额: $ 30万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1335276&HistoricalAwards=false
• 关键词: Nanofibers; Multilayered; Forced; Assembly; Polymer

This grant provides funding for the development of a novel processing approach for the scalable and versatile fabrication of polymer nanofibers. Specifically, the approach is based on an unusual combination of conventional polymer processing, namely co-extrusion, and multi-layering with transverse cutting. The major aims of this proposal are (1) to provide fundamental understanding of this novel process; (2) to assess the flexibility of the polymer systems amenable to nanofiber fabrication; and (3) to examine targeted biomedical applications which build upon orientation and cross-sectional variations. It is our goal to push the processing envelope to obtain small diameter nanofibers (for example, 75-200 nm) with variations in cross-sectional area to ultimately probe surface area and porosity limits. We will also integrate a fiber drawing unit with accurate temperature control immediately after the extrusion system as an in-situ takeoff and orienting unit, which will largely increase production efficiency and add significant strength to the fibers due to chain orientation.If successful, the results of this research will provide a deeper understanding of this novel process and a detailed assessment of the scope of polymer systems that are amenable to fiber fabrication via this unique process. Also, it is expected that the results of this research will reveal the potentially broad impact of the technology, with a specific focus on applications in the area of human health, including nanofiber scaffolding for regenerative medicine and drug delivery. The proposed work will be an important contribution to the area of polymer processing and can lay the foundation for an entirely new polymer nanofiber manufacturing process. Moreover, the work can lead to the development of important applications of polymer nanofibers that are impractical using conventional nanofiber processing methods.

这笔赠款为开发一种新型加工方法提供资金，以实现聚合物纳米纤维的可扩展和多功能制造。 具体来说，该方法基于传统聚合物加工的不寻常组合，即共挤出和横向切割的多层。 该提案的主要目的是（1）提供对这一新颖过程的基本理解； (2) 评估适合纳米纤维制造的聚合物系统的灵活性； (3) 研究基于方向和横截面变化的目标生物医学应用。 我们的目标是突破加工范围，获得横截面积变化的小直径纳米纤维（例如 75-200 nm），以最终探测表面积和孔隙率极限。我们还将在挤出系统之后立即集成具有精确温度控制的纤维拉伸装置，作为原位牵引和定向装置，这将大大提高生产效率，并由于链定向而显着增加纤维的强度。如果成功，结果这项研究将提供对这种新颖工艺的更深入的了解，并对适合通过这种独特工艺制造纤维的聚合物系统的范围进行详细评估。 此外，预计这项研究的结果将揭示该技术潜在的广泛影响，特别关注人类健康领域的应用，包括用于再生医学和药物输送的纳米纤维支架。 所提出的工作将对聚合物加工领域做出重要贡献，并可为全新的聚合物纳米纤维制造工艺奠定基础。 此外，这项工作可以促进聚合物纳米纤维重要应用的发展，而使用传统纳米纤维加工方法是不切实际的。