MRI: Acquisition of a High Sensitivity X-Detect NMR Instrument

MRI：购买高灵敏度 X 检测 NMR 仪器

• 批准号: 1334048
• 负责人: Gregory Tochtrop
• 金额: $ 46.43万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1334048&HistoricalAwards=false
• 关键词: MRI; Acquisition; Sensitivity; Detect; NMR

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Gregory Tochtrop from Case Western Reserve and colleague Blanton Tolbert will acquire a 500 MHz NMR spectrometer equipped with a liquid-nitrogen cooled broadband X-detect probe and an automated sampling system. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) studies of the catabolic fate of lipid peroxidation products; (b) NMR detection of RNA structures and protein-RNA contacts involved in viral replication; (c) studies of mechanically enhanced polymers; (d) advanced functional materials based upon organic conjugated polymers and molecules; (d) protein stability, structure, and dynamics; (e) interlocked polymeric architectures; (f) mechanisms by which enzymes are activated during signal transduction pathways; (g) characterization of conjugated molecules and polymers; and (h) design and characterization of fluoro-aromatic analogues of human insulin.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research of students in the departments of Chemistry, Biology, Polymer Science & Engineering, Chemical Engineering and Biomedical Engineering. The instrument will enhance the research and teaching capabilities of the greater Cleveland scientific community with web-based scheduling and cyber-enabled data delivery/processing for off-site users.

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Gregory Tochtrop from Case Western Reserve and colleague Blanton Tolbert will acquire a 500 MHz NMR spectrometer equipped with a liquid-nitrogen cooled broadband X-detect probe and an automated sampling system.该提案旨在增强各级研究和教育，尤其是在（a）研究脂质过氧化产物的分解代谢命运等领域； （b）与病毒复制有关的RNA结构和蛋白RNA接触的NMR检测； （c）机械增强的聚合物的研究； （d）基于有机共轭聚合物和分子的高级功能材料； （d）蛋白质稳定性，结构和动力学； （e）互锁的聚合结构； （f）在信号转导途径中激活酶的机制； （g）共轭分子和聚合物的表征； （H）人类胰岛素的氟芳族类似物的设计和表征。核磁共振（NMR）光谱是化学家可用的最强大工具之一，用于阐明分子结构。它用于识别未知物质，以表征分子中原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。这些NMR研究的结果将对合成有机/无机化学，材料化学和生物化学产生影响。该乐器将是教学的组成部分，也将是化学，生物学，聚合物科学与工程，化学工程和生物医学工程学系的学生的研究。该仪器将通过基于Web的调度和支持现场用户的数据交付/处理，增强大克利夫兰科学界的研究和教学能力。