Collaborative Research: Dakota Bioprocessing Consortium (DakotaBioCon)

合作研究：达科他生物加工联盟 (DakotaBioCon)

• 批准号: 1330842
• 负责人: James Rice
• 金额: $ 300万
• 依托单位: South Dakota State University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1330842&HistoricalAwards=false
• 关键词: Collaborative; Research; Dakota; Bioprocessing; Consortium

The Dakota Bioprocessing Consortium (DakotaBioCon) brings together researchers from four institutions in two neighboring states, North Dakota and South Dakota, with similar geographical, socio-economic and environmental diversity: North Dakota State University (NDSU), South Dakota State University (SDSU), University of North Dakota (UND) and South Dakota School of Mines & Technology (SDSMT). The vision of DakotaBioCon is through cutting-edge research and development to become a recognized intellectual leader in biomass bioprocessing that can help the region, nation and global society transition to a bio-based economy. The primary goal of DakotaBioCon is to establish a multi-state, multi-institution, multi-disciplinary, collaborative infrastructure to enable and facilitate the development of novel bioprocessing technologies for sustainable production of high-value chemicals and materials from renewable resources, with emphasis on lignin-derived products as economically viable substitutes for imported fossil-fuel based chemicals. DakotaBioCon achieves its goal of regional infrastructure development in the area of lignin bioprocessing through the accomplishment of several integrated objectives:1) Convert lignin into low molecular weight chemical fractions using a suite of novel processing methods, including high-temperature liquefaction and biodegradation of lignin, and analytical methods, (chromatography, spectrometry and chemical methods) to enable mass balance closure;2) Decipher the reaction mechanisms associated with the proposed lignin disassembly methods as a means to optimize and channel lignin fragmentation reaction pathways;3) Design process/purification schemes to convert precursor chemicals into valuable products;4) Develop new monomers/polymers and composites from lignin-derived aromatics/phenolics;5) Develop and upgrade the research and education infrastructure through joint collaborative activities that include sharing of data, knowledge, expertise, equipment, facilities, and educational programs.The impacts of DakotaBioCon are far-reaching, and extend beyond the award period. Bioprocessing of renewable resources addresses strategic national security priorities by reducing national dependence on imported oil and creates new jobs. To ensure continuation and long-term sustainability, DakotaBioCon leverages existing partnerships within UND's Sustainable Energy Research Initiative and Supporting Education (SUNRISE), SDSU's SunGrant Initiative, and SDSMT's Center for Bioprocessing Research and Development (CBRD) and future commercial intellectual property.Intellectual Merit:DakotaBioCon focuses on bioprocessing of lignin to renewable phenolics, aromatic chemicals and green polymers with potential uses as chemical and polymeric alternatives to petrochemicals. New knowledge and scientific contributions to the field of lignin bioprocessing are being generated. The intellectual merit of the proposed research approach is: 1) the potential for development of new, more cost-efficient and environmentally-friendly methods/agents for lignin depolymerization; 2) the potential for development of a suite of novel analytical methods enabling detailed product analysis; 3) the potential for deciphering the mechanistic aspects of lignin thermochemical and biological fragmentation to attain enhanced conversion rates and/or generate new lignin building-block precursors for industrial chemical processes; and 4) the potential for development of new, green materials with improved chemical and physical properties.Broader Impacts:DakotaBioCon infrastructure supports basic and applied research programs and offer expanded education, training and workforce development opportunities for a diverse cohort of K-12, undergraduate, and graduate students. It contributes to meeting national energy and economic security needs. These programs are leveraged to enhance collaboration, knowledge, and resource-sharing in the growing interdisciplinary field of renewable energy and materials. The education and workforce development strategy of DakotaBioCon are characterized by an interdisciplinary approach and a unique web of partnerships that helps advance these programs to the next level of performance and delivery. Research findings are widely disseminated to the scientific community and public through website, news media, radio, public databases, presentations at national and international meetings, and peer-reviewed publications in journals of international repute.

达科他州的生物加工联盟（Dakotabiocon）将来自北达科他州和南达科他州两个机构的研究人员汇集在一起​​，具有相似的地理，社会经济和环境多样性：北达科他州立大学（NDSU），南达科他州立大学（NDSU），南达科他州大学（NDSU），北达科他州大学（SDSU），北达科他州（SDSU），北达科他州（SDA），北达科他州（SDA）（SDA）（北达科他州）（SDA）（北达科他州）（北达科他州） （SDSMT）。 Dakotabiocon的愿景是通过尖端的研发和发展成为生物量生物处理的公认的知识分子领导者，可以帮助该地区，国家和全球社会向基于生物的经济过渡。 Dakotabiocon的主要目标是建立一种多国家，多机构，多学科的协作基础架构，以促进并促进新型的生物处理技术，以从可再生能源的可再生化学资源中可持续生产高价值化学物质和材料，并强调可再生能源化学产品，并强调木质素化的质量良好的替代产品，以实现易于实用的材料。 Dakotabiocon通过实现几个综合目标来实现木质素生物处理领域的区域基础设施发展的目标：1）使用一系列新型加工方法将木质素转化为低分子量的化学分数，包括一系列新型加工方法，包括高温液化液和化学方法的高温液体和化学方法，（和分析方法），（和分析方法），（和分析方法）（（闭合； 2）解释与拟议的木质素拆卸方法相关的反应机制，作为优化和引导木质素碎片反应途径的一种手段； 3）设计过程/纯化方案，以将前体化学物质转化为有价值的产品； 4）开发新的单体/聚合物，并通过木质素衍生的培训/落下的静电素化； 5）包括分享数据，知识，专业知识，设备，设施和教育计划的活动。Dakotabiocon的影响是深远的，并且超出了奖励期。可再生资源的生物处理通过减少国家对进口石油的依赖并创造新的工作来解决战略国家安全的重点。为了确保延续和长期可持续性，Dakotabiocon利用UND的可持续能源研究计划和支持教育（Sunrise），SDSU的Sungrant Initiative以及SDSMT的生物强化研究与发展中心（CBRD）和未来的商业知识属性：Intellectual：dakotabiocon for of to rignecon compoicon for lignecon optin for lign optin compoicocon comportin，具有潜在用途作为化学和聚合物替代石化物质的酚类，芳香化学物质和绿色聚合物。正在产生对木质素生物处理领域的新知识和科学贡献。拟议的研究方法的智力优点是：1）开发新的，更具成本效益和环保的方法/代理来开发木质素去聚合的潜力； 2）开发一套新的分析方法的潜力，以实现详细的产品分析； 3）破译木质素热化学和生物碎片的机械方面的潜力，以达到提高的转化率和/或为工业化学过程产生新的木质素建筑物块前体； 4）开发具有改进化学和物理特性的新绿色材料的潜力。BRODER的影响：Dakotabiocon基础设施支持基本和应用的研究计划，并为各种K-112，本科生和研究生提供扩展的教育，培训和劳动力发展机会。它有助于满足国家能源和经济安全需求。这些计划的利用是为了增强可再生能源和材料跨学科领域的协作，知识和资源共享。 Dakotabiocon的教育和劳动力发展策略的特征是跨学科的方法和独特的合作伙伴网络，可帮助将这些计划提高到更高的绩效和交付水平。通过网站，新闻媒体，广播，公共数据库，国家和国际会议上的演讲以及在国际声誉期刊中经过同行评审的出版物，通过网站，新闻媒体，广播，公共数据库，演讲将研究发现广泛传播给科学界和公众。