SBIR Phase I: Osteoconduction Determination of Mineral Coated Silicon Dioxide Nanosprings

SBIR 第一阶段：矿物涂层二氧化硅纳米弹簧的骨传导测定

• 批准号: 1315050
• 负责人: Jamie Hass
• 金额: $ 15万
• 依托单位: MJ3 Industries
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1315050&HistoricalAwards=false
• 关键词: SBIR; Phase; Osteoconduction; Determination; Mineral

This Small Business Innovation Research Phase 1 project addresses the failure of osseointegration, the lack of bonding between an orthopedic device and bone. Failure of the implant does occur with an unacceptably high rate (8-20%). The main driver for revision surgery is aseptic loosening of the implant, which occurs at a nanoscale. This can be very detrimental to the patient since the revised implants have higher complication rates. The research objective is to develop an orthopedic implant coating that mimics both the scaffolding and mineral structure of healing woven bone. Coated nanosprings, a synthetic collagen nanobiomaterial, mimics the scaffolding component of bone. This proposal is directed at developing a mineral layer on the nanosprings to make synthetic woven bone. Nanosprings can be grown on orthopedic devices. Metal alloy coated nanosprings are well tolerated by the body and increase the bone deposition rate, but the procedure is expensive. The mineral used for the proposed coating is inexpensive but lacks the scaffolding effects needed for bone integration. Combining these two synthetic biomaterials would provide the necessary economical scaffolding to facilitate osseointegration.The broader impact/commercial potential of this project to the osteoconductive biomaterial market is vast. The orthopedic market is a multi-billion dollar industry, which will increase as the baby boomer population ages. This technology can be employed in both animal and human devices, such as dental implants, prosthetics, and joint replacements. The potential commercialization options are partnering with an existing orthopedic device manufacturer for this add-on coating, or direct sales to the animal market, and then to the human market as the FDA allows. The coated nanosprings have the ability to greatly increase the rate and hardness of bone deposition. It is hypothesized that this increase around implants can have a significant clinical impact to improve the quality of patient?s lives as well as an economical benefit. This new technology can provide employment for scientists in both biologic and other hard science fields. The nanosprings are an ideal foundation for osteoconductive research. This synthetic collagen allows different coating material to be studied at a nanoscale level. Thus, providing both materials and biologic insight to the osseointegration process.

这个小型企业创新研究阶段1项目解决了骨整合的失败，骨科设备和骨骼之间缺乏键合。植入物的失败确实会出现不可接受的高率（8-20％）。修改手术的主要驱动因素是植入物的无菌松动，该植入物发生在纳米级。由于修订后的植入物的并发症发生率较高，因此这可能对患者非常有害。研究目标是开发一种骨科植入物涂料，该涂层都模仿了愈合编织骨的脚手架和矿物结构。涂层纳米普林斯是一种合成胶原蛋白纳米材料，模仿骨的脚手架成分。该提案是针对在纳米弹簧上开发矿物质层以制成合成织骨的。可以在骨科设备上生长纳米弹簧。金属合金涂层的纳米弹簧可以很好地耐受人体的耐受性并增加骨沉积速率，但是该过程很昂贵。用于涂层的矿物质廉价，但缺乏骨骼整合所需的脚手架效应。将这两个合成生物材料结合起来将提供必要的经济脚手架以促进骨整合。该项目对整骨的生物材料市场的更广泛的影响/商业潜力非常广泛。骨科市场是一个数十亿美元的行业，随着婴儿潮一代人口年龄的增长，它将增加。该技术可用于动物和人类设备，例如牙科植入物，假肢和关节替代品。潜在的商业化选项正在与现有的骨科设备制造商合作，以供此附加涂料或直接销售动物市场，然后在FDA允许的情况下与人类市场。涂层的纳米弹簧有能力大大提高骨沉积的速率和硬度。假设植入物周围的增加可以产生重大的临床影响，以改善患者生活的质量以及经济益处。这项新技术可以为生物学和其他硬科学领域的科学家提供就业。 纳米弹簧是骨导导性研究的理想基础。该合成胶原蛋白允许在纳米级水平上研究不同的涂层材料。因此，将材料和生物学见解提供给骨整合过程。