Novel Approaches to Carbonyl alpha-Functionalization

羰基 α 官能化的新方法

• 批准号: 1300652
• 负责人: Don Coltart
• 金额: $ 40.5万
• 依托单位: University of Houston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1300652&HistoricalAwards=false
• 关键词: Novel; Approaches; Carbonyl; alpha; Functionalization

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Don Coltart of the Department of Chemistry at the University of Houston will explore the development of approaches to the challenging and long-standing problem ofasymmetric alpha-functionalization of ketones. The central hypothesis of the research is that activated hydrazones and oximes will provide the basis for a variety of new approaches to the asymmetric alpha-alkylation/functionalization of aldehydes and/or ketones. For ketone derived systems, fundamentally new substitution patterns that cannot be generated using existing technology will be accessible in an asymmetric manner. For both aldehydes and ketones, it will be possible to conduct asymmetric alpha-alkylation/functionalization in an umploung sense relative to typical methods, thus enabling the incorporation of functionality that cannot be introduced using enolate based methods.This project focuses on developing more efficient methods for the preparation of complex organic molecules. The methods that will be developed are designed to be very general, and will therefore be directly applicable to the asymmetric synthesis of a wide range of biologically important natural products, drugs, and related compounds. Consequently, they stand to find wide use by researchers in academic, government, and private sectors. In addition, this project will provide excellent training of students, from pre-undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences.

在化学部化学综合计划资助的该项目中，休斯顿大学化学系的唐·科尔塔特（Don Coltart）教授将探讨开发酮的挑战性且长期存在的问题的方法。这项研究的中心假设是，活化的音带和氧化物将为醛和/或酮的不对称α-烷基化/功能化的各种新方法提供基础。 对于酮派生的系统，从根本上讲，无法使用现有技术生成的新替代模式将以不对称的方式访问。对于醛和酮，相对于典型方法，可以在UMPLUNG的感觉中进行不对称的α-烷基化/功能化，从而使能够使用基于培养基的方法引入功能性的合并。该项目重点是开发更有效的方法，以制备复杂有机体的制备方法。 将要开发的方法设计为非常笼统，因此将直接适用于多种生物学上重要的天然产物，药物和相关化合物的不对称合成。因此，他们将发现研究人员在学术，政府和私营部门中广泛使用。此外，该项目将提供从学前班到博士后的学生进行的出色培训，包括科学历史上人数不足的小组的学生。