I-Corps: Isosorbide-based Renewabl Humectants to Replace Polyethylene Glycol

I-Corps：基于异山梨醇的可再生保湿剂取代聚乙二醇

• 批准号: 1261924
• 负责人: Michael Jaffe
• 金额: $ 5万
• 依托单位: New Jersey Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-10-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1261924&HistoricalAwards=false
• 关键词: Corps; Isosorbide; based; Renewabl; Humectants

This project is focused on producing mesogenic polyesters containing isosorbide. The work has taken two approaches: (1) Introducing isosorbide into known LCP backbone as a "disruptor" for brick dust LCPs such as poly (p-hydroxybenzoic acid); and (2) As part of a hydroxyacid mesogen formed by reacting isosorbide with a suitable mesogen. The mechanism of water uptake in isosorbide compounds was investigated and control of water uptake in these compounds was demonstrated. A result of these studies on how to design hydrophobic isosorbide compounds is a similar understanding of the structure of isosorbide compounds with high and controlled hydrophilicity. This has led to the identification, synthesis and characterization of highly hydrophilic, glycerol linked isosorbide oligomers and polymers as effective replacements for the commonly utilized poly (ethylene glycol, PEG) as a humectant in many personal care, cosmetic and biomedical products. Currently, ethylene glycol and its polymeric forms is an industrial staple. A dominant use is as a reactant, making hydrophobic chemicals hydrophilic. The major forms are polyethylene glycols (PEG) as solvents, emulsifiers, and to enable greater water miscibility(surfactants). Principal markets of use are pharmacy, personal care, paints and inks, oil extraction and grain products (de-dusting). In recent years the trend toward PEG-free products has grown rapidly. Currently a PEG-free solubilization alternative, composed of pentylene glycol with surfactants, is available to help to dissolve lipophilic substances such as perfume, essential oils, active ingredients and vitamins in pure aqueous and aqueous/alcoholic formulations. The isosorbide derivative this project focuses on is a renewable corn-derived material that will perform similarly, but will open a new field of hydrophilicity chemistry because of the unique stereo chemical make-up of this new oligomer.

该项目的重点是生产含有异森质的介体聚酯。这项工作采用了两种方法：（1）将异氧化物引入已知的LCP主链中，作为砖尘LCP的“破坏者”，例如poly（p-Hydroxybenzoic Acid）； （2）作为通过与合适的中质核苷反应形成的羟基酸中蛋白素的一部分。研究了异氧化物化合物中的水吸收机制，并证明了这些化合物中水吸收的控制。这些有关如何设计疏水性异索核苷化合物的研究的结果是对具有高和受控亲水性的异索核苷化合物的结构的类似理解。这导致了高度亲水性，甘油连接的异糖性寡聚物和聚合物的鉴定，合成和表征，作为在许多个人护理，化妆品和生物医学产品中，作为常用的聚（乙烯甘油，PEG）的有效替代。目前，乙二醇及其聚合物形式是工业主食。主要用途是作为反应物，使疏水性化学物质亲水。主要形式是聚乙烯甘油（PEG）作为溶剂，乳化剂，并使水更易于能力（表面活性剂）。主要使用市场是药房，个人护理，油漆和油墨，油提取和谷物产品（折叠）。近年来，无PEG产品的趋势迅速增长。目前，由甲基乙二醇与表面活性剂组成的无PEG溶解化替代品可帮助溶解纯水性和水性/酒精制剂中的诸如香水，精油，活性成分和维生素等亲脂性物质。该项目的重点是异肌衍生物，是一种可再生的玉米衍生材料，其性能类似，但由于这种新的低聚物的独特立体化学化妆，将打开一个新的亲水性化学领域。