Entrainment and Detection of Engineered Nanoparticles

工程纳米粒子的夹带和检测

• 批准号: 1236909
• 负责人: Richard Flagan
• 金额: $ 30万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1236909&HistoricalAwards=false
• 关键词: Entrainment; Detection; Engineered; Nanoparticles

CBET-1236909The proposed research addresses the need to understand workplace exposures to engineered nanoparticlesin two ways: (i) by investigating fundamental mechanisms by which engineered nanoparticlesmay become airborne; and (ii) by developing aerosol instruments suitable for routine workplace andpersonal monitoring of nanoparticles in the 1-500 nm size range with the ability to follow transientthat may be responsible for most exposure from well-designed nanoparticle synthesis systems.Controlled laboratory experiments will also be conducted to develop a fundamental understandingof mechanisms for nanoparticle release to the air, beginning with studies of the aerodynamicentrainment from nanoparticle-coated surfaces. The long-standing need for suitable instrumentsfor monitoring workplace exposures will be addressed by creating a small, simple, and low costnanoparticle opposed migration aerosol detector (NOMAD) that will enable exposure assessmentwith sufficient resolution to estimate lung deposition patterns. The NOMAD performance will becompared with conventional approaches to exposure monitoring in nanotechnology laboratories, andprovide personal exposure data that is not presently possible.Intellectual merit: The proposed research will survey sources of airborne nanoparticles usingsize resolved instruments with better time response, and broader coverage of the potential sizerange than employed in previous studies, thereby enabling detection of transient release events, andfacilitating identification of nanoparticle sources. Subsequent controlled laboratory experiments willquantify the forces required to entrain nanoparticles from different kinds of surface deposits, and theextent of agglomeration the airborne nanoparticles that result, thereby laying the groundwork fora fundamental understanding of potential exposure mechanisms. The new instruments will enablehealth effects studies that are clearly needed to understand the risks of nanotechnology, but arenot presently possible due to the cost and complexity of present instruments. With these tools,continuous exposure data will become a valuable tool in both health effect research and in workerprotection. They will further enable studies of exposures to nanoparticles in the use of consumernanotechnology products, and from conventional pollution sources.Broader impacts: The proposed research will provide new insights into incidental processesthat contribute to the release of engineered nanoparticles into workplace air, and the risks associatedwith such releases. The new airborne nanoparticle detectors will enable researchers and industry tomonitor nanoparticle exposures with rigor that is not now possible. Moreover, these new detectorsshould become the enabling technology for health effects studies that are clearly needed, but notpresently possible.Undergraduates will have the opportunity to become involved in the project through Caltech?sSummer Undergraduate Research Fellowship (SURF). In addition, the Flagan laboratory will recruitparticipants from the Minority Undergraduate Research Fellowship (MURF) program as it has in4 of the last 6 years. We will work with Caltech?s outreach program to invite local area students tolectures and visits to our laboratory, as well as talk to the students in their schools. Students fromlocal high schools, particularly those near freeways, will be recruited to undertake science projectsinvolving measurements of nanoparticles in their home or school environments.As he has done for 10 years, the PI will continue to co-mentor a First Robotics team at RamonaConvent Secondary School, a girls high school in Alhambra, CA that has 60% minority enrollment.This has proven to be a most effective mechanism in stimulating interest in pursuing STEM studiesin college by showing the students that engineering is fun.

CBET-1236909拟议的研究涉及在两种方法中了解工作场所在工程纳米颗粒上暴露的有必要：（i）通过研究基本机制，通过这些基本机制，工程纳米颗粒可能会成为空降； （ii）通过开发适用于1-500 nm尺寸范围内纳米颗粒的常规工作场所和人格监测的气溶胶仪器，并且可以遵循瞬时的能力可能导致大多数从设计良好的纳米颗粒合成系统暴露。从纳米颗粒包被涂层表面的空气原理启动开始，进行了纳米颗粒释放的基本理解机制的基本理解。长期以来对监测工作场所暴露的适当工具的需求将通过创建相反的迁移气溶胶检测器（NOMAD）来解决，以估算足够的分辨率以估算肺部沉积模式。游牧绩效将采用纳米技术实验室中暴露监测的常规方法，并提供目前不可能的个人暴露数据。潜在的Sizerange比以前的研究所使用的，从而实现了瞬态释放事件的检测，并鉴定了纳米颗粒来源的鉴定。随后的受控实验室实验将使从不同种类的表面沉积物中吸收纳米颗粒所需的力，以及凝聚的extentent会导致的空气中纳米颗粒，从而对潜在暴露机制进行基本理解。新工具将启用健康效果研究，这些研究显然需要了解纳米技术的风险，但是由于目前的工具的成本和复杂性，目前可能会出现Arenot。借助这些工具，连续暴露数据将成为健康效应研究和工人保护的宝贵工具。他们将进一步研究消费技术产品中对纳米颗粒的暴露，以及从常规污染来源进行的。BRODER的影响：拟议的研究将为偶然的Processesthat提供新的见解，从而有助于将工程纳米粒子释放到工作场所中，以及与与工作场所的空气释放的风险，以及与之相关的风险。这样的版本。新的机载纳米颗粒探测器将使研究人员和行业的纳米粒子以严格的态度暴露，这是不可能的。此外，这些新的检测器应该成为明显需要的健康效应研究的能力技术，但不可能。毕业生将有机会通过Caltech？ssummer本科研究奖学金（SURF）参与该项目。此外，Flagan实验室将从少数族裔本科研究奖学金（MURF）计划中招募参与者，因为它在过去6年中已有4年。我们将与加州理工大学的外展计划合作，邀请当地学生的宽容和访问我们的实验室，并与学校的学生进行交谈。将招募来自局部高中的学生，特别是在高速公路附近的学生，以在其家庭或学校环境中进行纳米颗粒的测量。他已经完成了10年的时间，PI将继续在RamonAconaConaConaConaConaConaConecon的第一家机器人团队中占领。学校是加利福尼亚州阿尔罕布拉邦的一所女子高中，有60％的少数族裔入学率。这被证明是通过向学生展示工程学很有趣的学生来刺激刺激STEM研究的最有效机制。