MRI: Acquisition of a 50 nm Resolution X-ray Computed Tomography Instrument

MRI：获取 50 nm 分辨率 X 射线计算机断层扫描仪

• 批准号: 1229090
• 负责人: Shawn Litster
• 金额: $ 129.04万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229090&HistoricalAwards=false
• 关键词: MRI; Acquisition; 50; nm; Resolution

This MRI grant is for the acquisition of a nano-scale resolution X-ray computed tomography (nano-CT) instrument that provides 3D volumetric imaging within opaque structures at 50 nm resolution. Nano-CT offers a unique set of capabilities compared to other imaging techniques and other available X-ray CT instruments. The particular nano-CT provides visualization inside materials and devices with 50 nm or 150 nm resolution with large 3D fields of view of 15 µm and 60 µm, respectively. This is the highest X-ray CT resolution available outside of large-scale synchrotron facilities. The high resolution is obtained even with soft materials, such as polymers, through a combination of a Fresnel zone plate objective and Zernike phase contrast imaging. Compared to techniques using sectioning, nano-CT is non-destructive and sample remains intact. Furthermore, the imaging is done in ambient or controlled environments without vacuum. These features combined with the nano-CT?s long working distance enable in-situ, in-operando, and time-history (4D) imaging. The nano-CT will be used in a wide array of projects across the colleges of science and engineering at Carnegie Mellon, with the enabled research falling into the major themes of: a) Energy and the environment, b) Micro/Nano materials and fabrication, and c) Biomedical and life sciences.The nano-CT will be a unique resource at Carnegie Mellon and at the regional and national levels, attracting external users from academia, industry, and national labs. The nano-CT will be installed alongside an existing custom micro-CT that offers a maximum resolution of 0.5-1 µm and large fields of view. These combined instruments will form a versatile multi-scale CT imaging facility, with imaging length scales ranging five orders of magnitudes, O(10 nm) to O(1 mm). This comprehensive facility will be advertised through a dedicated website and an annual user group meeting will be held to promote information exchanges and collaborations between the diverse set of users. In addition, workshops will be held to introduce industry to X-ray CT and nano-CT. The nano-CT will result in the training of a large number of student researchers from diverse areas, inspiring interdisciplinary collaborations. The nano-CT and its data will be integrated into existing outreach efforts and classes. To support this effort, a fixed number of zero user cost scans will be made available annually for education and outreach activities.

该MRI赠款是用于获取纳米级分辨率X射线计算机断层扫描（Nano-CT）仪器，该仪器在50 nm分辨率下提供不透明结构内的3D体积成像。与其他成像技术和其他可用的X射线CT仪器相比，Nano-CT提供了独特的功能。特定的纳米CT可在材料和设备内提供50 nm或150 nm分辨率的可视化，分别具有15 µm和60 µm的大型3D视野。这是在大规模同步设备之外提供的最高X射线CT分辨率。即使使用菲涅尔区板板物镜和Zernike相对比成像的组合，也可以使用软材料（例如聚合物）获得高分辨率。与使用切片的技术相比，纳米CT是无损的，样品仍然完好无损。此外，成像是在没有真空的环境或受控环境中进行的。这些特征结合了纳米ct的长度工作距离，使原地，operando和时间历史（4D）成像。 NANO-CT将用于卡内基梅隆的科学与工程学院的各种各样的项目中，使该研究属于：a）能量和环境的主要主题：a）能量和环境，b）微型/纳米材料和制造，c）生物医学和生活科学。行业和国家实验室。纳米CT将与现有的自定义微型CT一起安装，该自定义Micro-CT的最大分辨率为0.5-1 µm和大型视野。这些组合的仪器将形成多功能的多尺度CT成像设施，成像长度尺度范围为五个尺寸，O（10 nm）到O（1 mm）。该全面的设施将通过专门的网站进行广告，并将举行年度用户组会议，以促进潜水员用户集合之间的信息交流和协作。此外，将举办研讨会将行业引入X射线CT和Nano-CT。纳米CT将导致培训来自潜水员领域的大量学生研究人员，从而激发了跨学科的合作。纳米-CT及其数据将集成到现有的外展工作和班级中。为了支持这项工作，每年将提供固定数量的零用户成本扫描以进行教育和外展活动。