SBIR Phase I: 'Smart Filter' for Fast Chemical Reaction Clean-up

SBIR 第一阶段：用于快速化学反应清理的“智能过滤器”

• 批准号: 1215094
• 负责人: Bo Xu
• 金额: $ 15万
• 依托单位: Rigid Solutions LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1215094&HistoricalAwards=false
• 关键词: SBIR; Phase; Smart; Filter; Fast

This Small Business Innovation Research Phase I project entitled ?Smart Filter for Fast Chemical Reaction Clean-up? tackles an important problem in the manufacturing industry, namely, the labor-intensive nature of chemical synthesis and its hazardous conditions, which, unfortunately, have not changed much in the last 60 years. Our novel concept of ?rigid solvent extraction? speeds up reaction clean-up, by elimination of the liquid-liquid extraction step. The idea is very simple: reactions are conducted in the usual way and quenched with a suitable aqueous solution; however, instead of using relatively large amounts of organic solvent to extract the aqueous/organic mixture, we use a solid supported organic liquid phase (that we call a ?rigid solvent? phase). ?Rigid solvents? are easier to handle than liquids. Our clean-up cartridge design is also simple, it is a cartridge filled with highly porous rigid organic polymer. The reaction cleanup cartridges address the technology gap that exists between the deployment of high throughput synthesis and the analytical advances in chromatography columns. Because the workup step that lies between the synthesis of a compound and its final purification is laborious our technology will significantly close that gap providing an efficient and safe handling alternative of potentially hazardous chemistries. The broader impact/commercial potential of this project lies in its potential to reduce costs and improve safety in chemical operations during the discovery stage of most chemical manufacturing processes, including pharmaceuticals, agrochemicals, or advanced materials, a large number of compounds need to be prepared in amounts that range from mg to g or kg. An estimated 10,000 compounds are tested on average during drug discovery and preclinical stages in order to come up with one successful drug. And the individual synthesis of these thousands of compounds require between five to ten synthetic steps each from commercially available raw materials. The sheer number of compounds that need to be synthesized constitutes a nightmare scenario for medicinal chemists. The labor intensive nature of reaction clean-ups and rising labor costs have caused the outsourcing of synthetic chemistry work, traditionally conducted in the US, to other developing countries that have cheaper labor, less stringent worker protection, and lax waste disposal regulations. Our company ? Rigid Solutions, aims to develop an automation product that can make synthetic chemistry less labor-intensive and offer better protection for workers from hazardous substances, thereby reducing labor costs, synthesis time, and waste, and helping to keep chemical synthesis jobs in the US.

这个小型企业创新研究阶段I项目标题为“智能过滤器，用于快速化学反应清理？解决制造业中一个重要的问题，即化学合成及其危险条件的劳动密集型性质，不幸的是，在过去的60年中，这并没有太大变化。我们的新颖概念是刚性溶剂提取？通过消除液 - 液体提取步骤来加速反应清理。这个想法非常简单：反应以通常的方式进行，并用合适的水溶液淬火；但是，我们没有使用相对较大的有机溶剂来提取水性/有机混合物，而是使用固体支持的有机液相（我们称为“刚性溶剂？相）”。刚性溶剂？比液体更容易处理。我们的清理墨盒设计也很简单，它是一个装有高度多孔刚性有机聚合物的墨盒。反应清理弹药筒解决了高通量合成的部署与色谱柱中的分析进步之间存在的技术差距。因为在合成化合物及其最终纯化之间的工作步骤很费力，我们的技术将大大缩小该差距，从而为潜在的危险化学物质提供了有效且安全的处理替代方案。该项目的更广泛的影响/商业潜力在于其在大多数化学制造工艺的发现阶段，包括药品，农产品或先进材料在内的发现阶段的潜力，并提高化学操作的安全性，需要以从MG到G或kg或kg或kg进行大量化合物。在药物发现和临床前阶段，平均测试了估计10,000种化合物，以提出一种成功的药物。这些成千上万种化合物的单个合成需要从市售原材料中分别为五到十个合成步骤。需要合成的大量化合物构成了药物化学家的噩梦。反应清理和劳动力成本上升的劳动密集型性质导致了传统在美国进行的合成化学工作外包，这些工作在美国进行的其他发展中国家，劳动力较低，工人保护和宽松的废物处理法规。我们的公司？刚性解决方案旨在开发一种自动化产品，该产品可以使合成化学的劳动力降低，并为工人提供更好的保护免受危险物质的影响，从而减少人工成本，合成时间和浪费，并帮助在美国保持化学合成工作。