Collaborative Research: Large-Scale Nanomanufacturing of Well-Positioned and Highly Aligned DNA Wires from a Capillary Bridge

合作研究：从毛细管桥大规模纳米制造定位良好且高度对齐的 DNA 线

• 批准号: 1153663
• 负责人: Zhiqun Lin
• 金额: $ 15.24万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1153663&HistoricalAwards=false
• 关键词: Collaborative; Research; Large; Scale; Nanomanufacturing

The research objective of this project is to develop simple yet robust methods for massively producing well-positioned nanostructured materials composed of DNA or DNA-based nanocomposites, which possess unprecedented regularity, over a large area (i.e., large scale). Subsequent functionalization of highly ordered DNA can serve as multifunctional materials for a variety of potential applications in nanoelectronic devices. Three specific research goals will be pursued throughout this proposed project: (1) Produce highly ordered structures of DNA and DNA-based nanocomposites by controlling the flow of an evaporating liquid. (2) Develop a reliable and scalable strategy for integrating individual nanoscale building blocks (i.e., DNA) into functional two-dimensional devices with high density. By performing two consecutive evaporation-induced self-assemblies, it is possible to create highly ordered 2D DNA nanowire arrays. (3) Understand the formation mechanisms of ordered structures. The ability to predict the length scale of periodicity, height, and width and compare them with experimental observations is key to the understanding on the structure formation. This research is transformative in that it seeks to mass produce high-density functional nanodevices and nanocircuits, built upon well-positioned, highly ordered DNA or DNA nanocomposites for use in nanoelectronics, nanotechnology, and biotechnology, thereby transitioning fundamental scientific discoveries into useful technologies. The research project will be integrated with nanoscience and nanoengineering education. The educational efforts include recruitment of female undergraduate students, recruitment of high school teachers and students with an emphasis on minority in summer to perform one week of research, and development of lesson plans on DNA and DNA-based nanocomposites by high-school female interns.

该项目的研究目标是开发简单而稳健的方法，用于大规模生产由 DNA 或基于 DNA 的纳米复合材料组成的定位良好的纳米结构材料，这些材料在大面积（即大规模）上具有前所未有的规律性。高度有序的 DNA 的后续功能化可以作为多功能材料，在纳米电子器件中具有多种潜在应用。整个拟议项目将追求三个具体研究目标：（1）通过控制蒸发液体的流动来生产高度有序的 DNA 结构和基于 DNA 的纳米复合材料。 (2) 制定可靠且可扩展的策略，将单个纳米级构建模块（即 DNA）集成到高密度的功能性二维器件中。通过执行两次连续的蒸发诱导自组装，可以创建高度有序的 2D DNA 纳米线阵列。 (3)了解有序结构的形成机制。预测周期性的长度尺度、高度和宽度并将其与实验观察结果进行比较的能力是理解结构形成的关键。这项研究具有变革性，因为它寻求大规模生产高密度功能性纳米器件和纳米电路，建立在位置良好、高度有序的 DNA 或 DNA 纳米复合材料的基础上，用于纳米电子学、纳米技术和生物技术，从而将基础科学发现转化为有用的技术。该研究项目将与纳米科学和纳米工程教育相结合。教育工作包括招收女本科生、招收高中教师和学生（重点是少数族裔）在夏季进行为期一周的研究，以及由高中女实习生制定 DNA 和基于 DNA 的纳米复合材料的课程计划。