SBIR Phase I: Fluidic Processor

SBIR 第一阶段：流体处理器

• 批准号: 1113588
• 负责人: Neil Picha
• 金额: $ 15万
• 依托单位: Cadence Fluidics Company
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1113588&HistoricalAwards=false
• 关键词: SBIR; Phase; Fluidic; Processor

This Small Business Innovation Research (SBIR) Phase I project will support the development of a fluidic processor capable of performing complex fluidic processes. In Phase I, we will demonstrate the utility of this device in two-dimensional liquid chromatography (2DLC), where existing valve technologies currently severely limit the performance of 2DLC. This project seeks to radically change the way fluids are moved, switched, processed, stored, and detected within a fluidics system. Current state-of-the-art fluid switching devices, such as rotary and solenoid valves, actuate in a single dimension thereby severely limiting the fluidic calculations and permutations that can be derived from single or even multiple concatenated devices. Furthermore, because they are one-dimensional devices, they have problems with analyte carry over, channel cross talk, and are generally design limited. This novel concept breaks down the traditional design barriers that constrain the implementation of current fluidics. To accomplish this, the concept transcends the single dimension and embraces two- and three-dimensional fluid processing in the context of a valve. The project will result in a random access, multi-dimensional, multi-purpose valve platform with specific application to metabolomics and proteomics separations. The broader impacts of this activity include application of the device to greatly expand research and analytical capabilities of instruments for 2-dimensional separations, food testing, drug discovery, GMO testing, and other critical analytical and bioprocessing applications. The device addresses the most vexing problem of interfacing of micro and macro fluidics and enables massively parallel manipulation of fluids. The project also will train and provide research experience for undergraduates. If successful, this project will contribute and enable new frontiers of systems biology research aimed at driving greater knowledge of biochemical interactions, mechanisms and biomarker discovery.

这项小型企业创新研究（SBIR）I期项目将支持能够执行复杂流体过程的流体处理器的开发。 在第一阶段，我们将在二维液相色谱法（2DLC）中演示该设备的实用性，其中现有的阀门技术目前严重限制了2DLC的性能。 该项目旨在从根本上改变流体在流体系统中移动，切换，处理，存储和检测的方式。当前的最新流体开关设备（例如旋转阀和电磁阀）在单个维度上启动，从而严重限制了可以从单个甚至多个串联设备得出的流体计算和排列。此外，由于它们是一维设备，因此它们在Canner，Channel Cross Talk上遇到问题，并且通常受到设计有限。这个新颖的概念打破了限制当前流体的传统设计障碍。为此，该概念超越了单个维度，并在阀的上下文中包含二维流体处理。该项目将导致随机访问，多维的多功能阀平台，并具有特定的代谢组学和蛋白质组学分离的应用。这项活动的更广泛影响包括将设备应用于大大扩展工具的研究和分析能力，用于二维分离，食物测试，药物发现，转基因生物测试以及其他关键的分析和生物处理应用。该设备解决了微流体和宏流体接口的最烦人的问题，并可以对流体进行大规模平行的操纵。该项目还将培训并为大学生提供研究经验。如果成功，该项目将为系统生物学研究的新领域提供贡献，旨在推动对生化相互作用，机制和生物标志物发现的更多了解。