Transient Intermediates in Proton and Electron Transfer

质子和电子转移中的瞬态中间体

• 批准号: 1055132
• 负责人: Frantisek Turecek
• 金额: $ 45.5万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1055132&HistoricalAwards=false
• 关键词: Transient; Intermediates; Proton; Electron; Transfer

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Frank Turecek of the University of Washington, for mass spectrometry studies of electron capture dissociation and electron transfer dissociation reactions in biomacromolecules. The goal of this research is to provide new identification methods for peptides and proteins, including structural features connected to non-covalent interactions (tertiary structure) and post-translational modifications.Broader impacts of the research are based on Professor Turecek's unique abilities to use his knowledge of organic ion reaction mechanisms and computational chemistry to assess energy distribution in these reactive intermediates, and his group's ability to design and build novel instrumentation for mass spectrometry. His research group gains expertise across a broad range of disciplines. The results of their investigations on peptide structure impact the fields of biochemistry and the pharmaceutical industry.

国家科学基金会化学部的化学结构，动力学和机制计划支持华盛顿大学的弗兰克·特雷克克（Frank Turecek）教授，用于电子捕获电子分离和电子转移解离反应的质谱研究。 这项研究的目的是为肽和蛋白质提供新的识别方法，包括与非共价相互作用（第三级结构）和翻译后修改有关的结构特征。研究的影响基于Turecek教授的独特能力，可利用他对这些有机离子反应机制和计算化学的知识和计算性化学的知识，并在这些构建中，并将其构建为构建，并在这些构建中，并在构建中，并将其构建构建在重生中，并在构建中，并将其构成及其构建的反应性化合物，并在既有反应性化的反应性化，并将其组成的反应性化合物纳入了反应性化学作用，并将其构建及其构建功能。光谱法。 他的研究小组在广泛的学科中获得了专业知识。 他们对肽结构的调查结果影响了生物化学和制药行业的领域。