Transient Intermediates in Proton and Electron Transfer

质子和电子转移中的瞬态中间体

• 批准号: 1055132
• 负责人: Frantisek Turecek
• 金额: $ 45.5万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1055132&HistoricalAwards=false
• 关键词: Transient; Intermediates; Proton; Electron; Transfer

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Frank Turecek of the University of Washington, for mass spectrometry studies of electron capture dissociation and electron transfer dissociation reactions in biomacromolecules. The goal of this research is to provide new identification methods for peptides and proteins, including structural features connected to non-covalent interactions (tertiary structure) and post-translational modifications.Broader impacts of the research are based on Professor Turecek's unique abilities to use his knowledge of organic ion reaction mechanisms and computational chemistry to assess energy distribution in these reactive intermediates, and his group's ability to design and build novel instrumentation for mass spectrometry. His research group gains expertise across a broad range of disciplines. The results of their investigations on peptide structure impact the fields of biochemistry and the pharmaceutical industry.

美国国家科学基金会化学部的化学结构、动力学和机制项目支持华盛顿大学的 Frank Turecek 教授进行生物大分子中电子捕获解离和电子转移解离反应的质谱研究。 这项研究的目标是为肽和蛋白质提供新的鉴定方法，包括与非共价相互作用（三级结构）和翻译后修饰相关的结构特征。该研究的更广泛影响基于 Turecek 教授利用他的独特能力有机离子反应机制和计算化学的知识，以评估这些反应中间体的能量分布，以及他的团队设计和建造新型质谱仪器的能力。 他的研究小组获得了广泛学科的专业知识。 他们对肽结构的研究结果影响了生物化学和制药行业。