RIG: Genetic mechanisms of detoxification in the cactophilic Drosophila mojavensis

RIG：嗜酸果蝇莫哈文西斯解毒的遗传机制

• 批准号: 1020009
• 负责人: Luciano Matzkin
• 金额: $ 17.97万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1020009&HistoricalAwards=false
• 关键词: RIG; Genetic; mechanisms; detoxification; cactophilic

Shifts in food resources are an influential force in the adaptation and evolution of species. This project focuses on the ability of the cactophilic fruit fly, Drosophila mojavensis, to detoxify the toxic compounds that are found in its food resource (necrotic cacti). Drosophila mojavensis is composed of four host races, each of which specializes on a different cactus species. Host races that use different cacti as food resources differ in some genes that appear to have played a role in the cactus specialization. The aim of this project is to quantify the performance of host race-specific alleles of two candidate detoxification genes by using experimental laboratory crosses to insert alleles found in one host race into the other and measuring the effect on performance on necrotic cactus. Improved knowledge of the genetics of resource specialization will increase understanding of the genetic basis of adaptation and the differentiation of species. The project will provide research based training and mentoring to undergraduates through collaboration with the California Alliance for Minority Participation Program. Undergraduates will attend the SACNAS and the Society for the Study of Evolution Conferences, where they will have the opportunity to interact with more senior scientists and present the results of their research.

食物资源的转移是物种适应和演变的影响力。 该项目的重点是仙人掌果蝇果蝇莫哈文斯蒂斯（Drosophila Mojavensis）对其食物资源（坏死性仙人掌）中发现的有毒化合物排毒的能力。 果蝇Mojavensis由四个宿主种族组成，每个种族都专门研究不同的仙人掌物种。 使用不同仙人掌作为食物资源的宿主种族在某些基因中似乎在仙人掌专业化中发挥了作用。 该项目的目的是量化两个候选排毒基因的宿主种族特异性等位基因的性能，通过使用实验室杂交将一种宿主种族中的等位基因插入另一个宿主的等位基因，并衡量对坏死仙人掌的性能的影响。 改善资源专业遗传学的知识将增加对适应遗传基础和物种分化的理解。 该项目将通过与加利福尼亚州少数民族参与计划的合作来为大学生提供基于研究的培训和指导。 本科生将参加SACNA和进化会议研究协会，在那里他们将有机会与更多的高级科学家进行互动并介绍他们的研究结果。