RUI: Diffusion of Cyclodexrtrins and Cyclodextrin Polymeric Nanoparticles in Mucus Studied by 19F Diffusion NMR

RUI：通过 19F 扩散 NMR 研究环糊精和环糊精聚合物纳米颗粒在粘液中的扩散

• 批准号: 1011836
• 负责人: Yong Ba
• 金额: $ 25万
• 依托单位: California State L A University Auxiliary Services Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1011836&HistoricalAwards=false
• 关键词: RUI; Diffusion; Cyclodexrtrins; Cyclodextrin; Polymeric

In this project supported by the Chemical Structure, Dynamics and Mechanisms Program of the Division of Chemistry, Professor Yong Ba of the California State University at Los Angeles will employ nuclear magnetic resonance (NMR) techniques to explore the diffusion of large molecules and polymeric nanoparticles in viscous liquids approximating biological mucus media. NMR diffusion studies will focus on fluorinated adamantane enclosed in different cyclodextrins in mucus models. The fluorinated adamantane will enable the exploration via the NMR active 19F nucleus, and diffusion parameters will be extracted using pulsed-field gradient techniques. The research will also involve the synthesis of cyclodextrin derivatives; characterization of these will entail mass spectrometric, proton NMR, and light scattering techniques. Cyclodextrin has potential as drug delivery vehicle, and an understanding of its diffusion properties across materials resembling nasal or gastrointestinal membranes is thus desirable. The PI will heavily rely on student contributions to research from the large pool of students from underrepresented minority groups at CSULA. Students involved in this research will have access to a modern NMR facility, where they will be introduced not only to specialized diffusion techniques, but conventional 1D and 2D NMR experiments as well.

在化学系化学结构、动力学和机理项目的支持下，加州州立大学洛杉矶分校的巴勇教授将利用核磁共振（NMR）技术来探索大分子和聚合物纳米颗粒在纳米粒子中的扩散。接近生物粘液介质的粘性液体。 NMR 扩散研究将重点关注粘液模型中不同环糊精中封装的氟化金刚烷。氟化金刚烷将能够通过 NMR 活性 19F 核进行探索，并使用脉冲场梯度技术提取扩散参数。该研究还将涉及环糊精衍生物的合成；这些的表征需要质谱、质子核磁共振和光散射技术。环糊精具有作为药物递送载体的潜力，因此需要了解其在类似于鼻膜或胃肠膜的材料中的扩散特性。 PI 将在很大程度上依赖 CSULA 大量来自代表性不足的少数群体的学生对研究的贡献。 参与这项研究的学生将有机会使用现代核磁共振设施，在那里他们不仅会学到专门的扩散技术，还会了解传统的一维和二维核磁共振实验。