Catalytic C-H Amination with Late Metal Nitrenes and Amides

后金属氮烯和酰胺的催化 C-H 胺化

• 批准号: 1012523
• 负责人: Timothy Warren
• 金额: $ 43.5万
• 依托单位: Georgetown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012523&HistoricalAwards=false
• 关键词: Catalytic; Amination; Late; Metal; Nitrenes

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Timothy H. Warren of Georgetown University will develop catalytic carbon-hydrogen (C-H) amination reactions as a means of preparing new carbon-nitrogen (C-N) bonds without the need to pre-functionalize the reactive sites. The ability to directly affect the C-H to C-N transformation without the need to isolate, purify, and transform corresponding precursors offers the appealing prospect of reduced cost, energy consumption and environmental impact. Building on previous results, this approach connects the chemical and electronic structures of copper and nickel nitrene and amide complexes to their catalytic reactivity. The work specifically examines copper and nickel nitrene complexes derived from organoazides, the amine and substrate scope of the reactions, and new catalysts architectures to further enhance the efficiency and scope of the catalytic reactions. The broader impacts of this project include national and international collaborations that will expand the student's perspective on the way science is conducted within the larger scientific community. Professor Warren is active in mentoring high school students, undergraduates (especially through the NSF-sponsored REU program) and graduate students.This work will expand the repertoire of methods that can be used in the chemical synthesis of compounds containing C-N bonds. The results of these studies could have many important long term impacts on a variety of applications in synthetic and materials chemistry, particularly in medicinal or pharmaceutical products.

在化学部化学催化计划资助的该项目中，乔治敦大学的蒂莫西·H·沃伦教授将开发催化碳 - 氢（C-H）胺化反应，作为准备新的碳硝基（C-N）键的手段，而无需预先实现反应性的部位。 无需隔离，净化和转换相应的前体即可直接影响C-H到C-N转化的能力，这是降低成本，能源消耗和环境影响的有吸引力的前景。 在先前的结果基础上，这种方法将铜和硝酸镍和酰胺复合物的化学和电子结构与它们的催化反应性联系起来。 这项工作专门研究了源自有机氮素，反应的胺和底物范围以及新的催化剂体系结构的铜和镍硝酸盐络合物，以进一步提高催化反应的效率和范围。 该项目的广泛影响包括国家和国际合作，将扩大学生对更大科学社区中科学的方式的看法。 沃伦教授积极指导高中生，本科生（尤其是通过NSF赞助的REU计划）和研究生。这项工作将扩大可用于化学合成含有C-N债券的化合物的方法的曲目。 这些研究的结果可能会对合成和材料化学的各种应用产生许多重要的长期影响，尤其是在药用或药品中。