EAGER: "Collaborative Research: Dynamic Melt Control for the Manufacture of Enhanced Polymer-Based Biomedical Devices"

EAGER：“合作研究：用于制造增强型聚合物生物医学设备的动态熔体控制”

• 批准号: 0961071
• 负责人: John Coulter
• 金额: $ 6万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0961071&HistoricalAwards=false
• 关键词: EAGER; Collaborative; Research; Dynamic; Melt

0961071 and 096174 collaborative proposal AbstractThe research objective of this EAGER award is to develop effective molecular orientation focused novel processing science for bioinert and biodegradable polymer systems. During recent years novel polymer melt manipulation techniques have been developed at Lehigh University. These techniques induce carefully designed polymer melt oscillation to align polymer molecules in desired ways during product manufacturing. Processing optimization will be assured via coupled studies of the mechanical and cellular response of resultant bio-polymer products. The project will further enhance the effectiveness of melt manipulation processing for localized product quality control, and do so specifically for polymers associated with biomedical applications. An interdisciplinary research team coupling strengths at Lehigh University and Virginia Polytechnic Institute and State University will explore the connections between applied melt manipulation conditions and final biomedical product quality attributes. Components of the study will explore 1) the development and assessment of novel routes to implement dynamic melt control; 2) the capability to reliably tune important biodegradable polymer product quality characteristics such as degradation kinetics via dynamic melt control during manufacturing; and 3) the level to which blood-polymer surface interactions can be influenced via dynamic melt control based product manufacturing. If successful, the results of this research will enable the development and cost effective manufacture of biopolymer-based medical devices with mechanical, blood interaction, and biodegradable properties tailored to specific biomedical applications. The advanced material processing techniques developed will enable production in a high-volume and low cost environment. To assure the societal relevance of the proposed research endeavor, significant industrial involvement and guidance will be included. The broader educational impact of the program will be enhanced by the inclusion of undergraduate students. In addition, numerous middle and high school students per year, the majority of which will be from under-represented and minority populations, will be exposed to the research as part of established and award winning programs that partner the two Universities with the surrounding school districts.

0961071 和 096174 合作提案 摘要 该 EAGER 奖的研究目标是为生物惰性和可生物降解聚合物系统开发有效的分子取向重点新型加工科学。近年来，里哈伊大学开发了新型聚合物熔体操纵技术。 这些技术引发精心设计的聚合物熔体振荡，从而在产品制造过程中以所需的方式排列聚合物分子。通过对所得生物聚合物产品的机械和细胞响应的联合研究，将确保加工优化。 该项目将进一步提高熔体操纵加工的有效性，以实现本地化产品质量控制，特别是与生物医学应用相关的聚合物。理海大学和弗吉尼亚理工学院及州立大学的跨学科研究团队将探索应用的熔体操作条件与最终生物医学产品质量属性之间的联系。该研究的组成部分将探索：1）开发和评估实施动态熔化控制的新途径； 2) 能够在制造过程中通过动态熔体控制可靠地调节重要的生物可降解聚合物产品质量特性，例如降解动力学； 3）通过基于动态熔体控制的产品制造可以影响血液-聚合物表面相互作用的水平。 如果成功，这项研究的结果将能够开发和成本有效地制造基于生物聚合物的医疗设备，这些设备具有针对特定生物医学应用的机械、血液相互作用和可生物降解的特性。开发的先进材料加工技术将使生产能够在大批量和低成本的环境中进行。 为了确保拟议研究工作的社会相关性，将包括重要的工业参与和指导。该计划更广泛的教育影响将通过本科生的加入而得到增强。 此外，作为两所大学与周边学区合作的既定获奖项目的一部分，每年有大量初中和高中学生（其中大多数来自弱势群体和少数族裔）将接触到这项研究。