MRI-R2: Acquisition of an Time of Flight Mass Spectrometry System for Interdisciplinary Research and Training at the University of Houston-Clear Lake

MRI-R2：休斯顿大学克利尔莱克分校采购飞行时间质谱系统用于跨学科研究和培训

• 批准号: 0958901
• 负责人: Zerong Wang
• 金额: $ 24.55万
• 依托单位: University of Houston - Clear Lake
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0958901&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; Time; Flight

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research and Instrumentation (MRI) program, Professors Zerong D. Wang, Lory Z. Santiago-Vazquez and Chunlong Zhang from the University of Houston at Clear Lake will acquire a liquid chromatography time-of-flight mass spectrometer (LC-TOF-MS) equipped with an electrospray ionization source (ESI). The instrumentation will support their research in the development of nucleoside analogs that may lead to potential anticancer and anti-HIV drugs, the design of remediation systems to support a green and sustainable environment, and the production of marine natural products with biological activity. Seven other faculty members at the University of Houston-Clear Lake will benefit in their studies of proteins and nucleic acids as well as organic and organometallic compounds.Mass spectrometry (MS) is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. The chromatography inlet will provide separation of complex mixtures before each component is analyzed. The time of flight mass analyzer has high sensitivity and mass accuracy to assist the analyses and interpretation of the resultant data. By using the LC/MS in research and laboratory courses, students will gain valuable experience with this modern instrument in a variety of applications across the disciplines of biology, chemistry, and environmental sciences.

该奖项由 2009 年美国复苏和再投资法案（公法 111-5）资助。该奖项由重大研究和仪器 (MRI) 项目授予，Zerong D. Wang 教授、Lory Z. Santiago-Vazquez 教授和张春龙教授休斯敦大学克利尔湖分校将购买一台配备电喷雾电离源 (ESI) 的液相色谱飞行时间质谱仪 (LC-TOF-MS)。这些仪器将支持他们在核苷类似物的开发方面的研究，这些核苷类似物可能会产生潜在的抗癌和抗艾滋病毒药物，设计修复系统以支持绿色和可持续的环境，以及生产具有生物活性的海洋天然产品。休斯敦大学克利尔湖分校的其他七名教员将受益于他们对蛋白质和核酸以及有机和有机金属化合物的研究。质谱 (MS) 用于通过测量样品的质量来鉴定样品的化学成分。样品中的分子成分被电离并被质谱仪检测后。色谱入口将在分析每种成分之前提供复杂混合物的分离。 飞行时间质量分析仪具有高灵敏度和质量准确度，有助于对结果数据进行分析和解释。 通过在研究和实验室课程中使用 LC/MS，学生将获得这种现代仪器在生物学、化学和环境科学学科的各种应用中的宝贵经验。