2010 Enzymes, Coenzymes, and Metabolic Pathways Gordon Research Conference in Waterville, NH on July 18-23

2010 年酶、辅酶和代谢途径戈登研究会议于 7 月 18 日至 23 日在新罕布什尔州沃特维尔举行

• 批准号: 0963698
• 负责人: Bruce Palfey
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0963698&HistoricalAwards=false
• 关键词: 2010; Enzymes; Coenzymes; Metabolic; Pathways

Intellectual MeritLife is controlled by chemistry. The thousands of vital chemical reactions that allow life are catalyzed by enzymes. Despite being studied systematically for more than a century, it is still not clear how enzymes accelerate chemical reactions. Enzymology has delved deeply into uncovering the mechanism of catalysis in biology and now attempts to understand reactivity in terms of macromolecular structure and in the dynamic motions of macromolecules. Structures and their movements promote some chemically complex, biologically critical reactions. Just as important, these same structures prevent deleterious side-reactions. The elegant tuning of enzyme reactivity is the result of evolution under selective pressure. Changing environments, or changing metabolic imperatives, cause new enzyme activities to evolve. The task of understanding how enzymes catalyze reactions, how their activity is controlled, and how new activities can emerge requires insight from many perspectives. This Gordon Conference on Enzymes, Coenzymes and Metabolic Pathways will provide a highly interactive venue to present discuss and debate the cutting-edge of enzyme research.Broader ImpactThe Gordon Research Conference (GRC) on Enzymes, Coenzymes and Metabolic Pathways is now one of the most influential in the broad area of enzymology. It gathers the leaders in the field, trainees at the student or postdoctoral level, and those in between. The collegial, informal atmosphere, coupled to the GRC non-disclosure policy, is extremely effective in fostering the free exchange of ideas and cutting-edge results. The Enzymes GRC has truly been the birthplace of many fruitful collaborations and new research directions. The Enzymes GRC has also been a very effective mechanism for incorporating women and underrepresented minorities into enzymology and the metabolic pathway community. The event allows participants to build invaluable networks with leaders in the field from academia, industry, and government. This year's conference continues this tradition of inclusiveness, with a very high proportion of speakers and discussion leaders being women and underrepresented minorities. The conference also provides important networking opportunities and intellectual development for graduate students and postdoctoral associated, and, therefore, helps to sustain the field by developing new talent.

Intellectual MeritLife 是由化学控制的。 维持生命的数以千计的重要化学反应都是由酶催化的。 尽管系统研究了一个多世纪，但仍然不清楚酶如何加速化学反应。 酶学深入研究揭示了生物学中的催化机制，现在试图理解大分子结构和大分子动态运动方面的反应性。 结构及其运动促进一些化学上复杂的、生物学上关键的反应。 同样重要的是，这些相同的结构可以防止有害的副反应。 酶反应性的优雅调节是选择压力下进化的结果。 环境的变化或代谢要求的变化会导致新的酶活性的进化。 了解酶如何催化反应、如何控制其活性以及如何出现新活性的任务需要从多个角度进行洞察。此次关于酶、辅酶和代谢途径的戈登会议将提供一个高度互动的场所，以讨论和辩论酶研究的前沿。更广泛的影响关于酶、辅酶和代谢途径的戈登研究会议 (GRC) 现在是最重要的会议之一在酶学领域具有重要影响。 它聚集了该领域的领导者、学生或博士后级别的学员以及介于两者之间的人员。 学院式、非正式的氛围，加上 GRC 的保密政策，对于促进思想和前沿成果的自由交流极为有效。 Enzymes GRC 确实是许多富有成效的合作和新研究方向的诞生地。 酶 GRC 也是将女性和代表性不足的少数群体纳入酶学和代谢途径社区的非常有效的机制。 该活动让参与者能够与学术界、工业界和政府领域的领导者建立宝贵的网络。 今年的会议延续了这种包容性的传统，发言者和讨论领袖中女性和代表性不足的少数族裔比例非常高。 该会议还为研究生和博士后相关人员提供了重要的交流机会和智力发展，因此有助于通过培养新人才来维持该领域。