2010 Enzymes, Coenzymes, and Metabolic Pathways Gordon Research Conference in Waterville, NH on July 18-23

2010 年酶、辅酶和代谢途径戈登研究会议于 7 月 18 日至 23 日在新罕布什尔州沃特维尔举行

• 批准号: 0963698
• 负责人: Bruce Palfey
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0963698&HistoricalAwards=false
• 关键词: 2010; Enzymes; Coenzymes; Metabolic; Pathways

Intellectual MeritLife is controlled by chemistry. The thousands of vital chemical reactions that allow life are catalyzed by enzymes. Despite being studied systematically for more than a century, it is still not clear how enzymes accelerate chemical reactions. Enzymology has delved deeply into uncovering the mechanism of catalysis in biology and now attempts to understand reactivity in terms of macromolecular structure and in the dynamic motions of macromolecules. Structures and their movements promote some chemically complex, biologically critical reactions. Just as important, these same structures prevent deleterious side-reactions. The elegant tuning of enzyme reactivity is the result of evolution under selective pressure. Changing environments, or changing metabolic imperatives, cause new enzyme activities to evolve. The task of understanding how enzymes catalyze reactions, how their activity is controlled, and how new activities can emerge requires insight from many perspectives. This Gordon Conference on Enzymes, Coenzymes and Metabolic Pathways will provide a highly interactive venue to present discuss and debate the cutting-edge of enzyme research.Broader ImpactThe Gordon Research Conference (GRC) on Enzymes, Coenzymes and Metabolic Pathways is now one of the most influential in the broad area of enzymology. It gathers the leaders in the field, trainees at the student or postdoctoral level, and those in between. The collegial, informal atmosphere, coupled to the GRC non-disclosure policy, is extremely effective in fostering the free exchange of ideas and cutting-edge results. The Enzymes GRC has truly been the birthplace of many fruitful collaborations and new research directions. The Enzymes GRC has also been a very effective mechanism for incorporating women and underrepresented minorities into enzymology and the metabolic pathway community. The event allows participants to build invaluable networks with leaders in the field from academia, industry, and government. This year's conference continues this tradition of inclusiveness, with a very high proportion of speakers and discussion leaders being women and underrepresented minorities. The conference also provides important networking opportunities and intellectual development for graduate students and postdoctoral associated, and, therefore, helps to sustain the field by developing new talent.

智力绩效受到化学控制。 允许寿命的数千种重要化学反应被酶催化。 尽管有系统地研究了一个多世纪，但尚不清楚酶如何加速化学反应。 酶学已深入研究生物学中催化的机制，现在试图从大分子结构和大分子的动态运动中理解反应性。 结构及其运动促进了一些化学复杂的，生物学上关键的反应。 同样重要的是，这些相同的结构阻止了有害的副反应。 酶反应性的优雅调整是选择性压力下进化的结果。 改变环境或改变代谢要求，会导致新的酶活性发展。 理解酶如何催化反应，如何控制其活动以及如何出现新活动的任务需要从许多角度洞悉。这次关于酶，辅酶和代谢途径的戈登会议将提供一个高度互动的场地，以讨论和辩论酶研究的尖端。BroaderImplastthe The Gordon Research Conferition（GRC）涉及酶，辅酶和代谢途径的戈登研究会议（GRC）现在是Enzyzymology广泛领域中最具影响力的酶。 它聚集了该领域的领导者，学生或博士后一级的学员以及介于两者之间的领导者。 结合GRC不披露政策的合作，非正式氛围在促进自由交流和尖端结果方面非常有效。 酶GRC确实是许多富有成果的合作和新研究方向的发源地。 酶GRC也是将妇女和代表性不足的少数民族纳入酶学和代谢途径社区的非常有效的机制。 该活动允许参与者与学术界，工业和政府领域的领导者建立宝贵的网络。 今年的会议延续了这一包容性传统，发言人和讨论领导者比例很高，是妇女和代表性不足的少数群体。 该会议还为研究生和博士后相关的社交机会和智力发展提供了重要的联系，因此，通过培养新的人才有助于维持该领域。