CAREER: Well-Defined Cyclic and Linear Poly(alpha-peptoid)s and Their Block Copolymers: Synthesis, Characterization and Solution Self-Assembly

职业：明确的环状和线性聚（α-类肽）及其嵌段共聚物：合成、表征和溶液自组装

• 批准号: 0955820
• 负责人: Donghui Zhang
• 金额: $ 64万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0955820&HistoricalAwards=false
• 关键词: CAREER; Well; Defined; Cyclic; Linear

In this CAREER project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Donghui Zhang of the Louisiana State University (LSU) will carry out research to develop new polymerization methods for N-substituted-N-carboxyl anhydrides. Zhang will study the kinetics and mechanism of the ring-opening polymerization of N-substituted-N-carboxyl anhydrides mediated by nucleophilic N-heterocyclic carbenes. Various cyclic and linear block copolymers will be prepared and the types of aggregates that they form in solution will be studied. The educational plan focuses on incorporating concepts from the research project into courses at LSU and on improving LSU K-12 outreach programs, including ChemDemo and "You Be the Chemist." This work will broaden the array of biologically related polymers that scientists can use to develop new polymers and materials. Besides developing new methodologies, the proposed research will enable researchers to create biomimetic polymers that could find application in bioimaging and biomedical technologies.

在这个由化学系高分子、超分子和纳米化学项目资助的CAREER项目中，路易斯安那州立大学（LSU）的张东辉将开展研究，开发N-取代-N-羧基酸酐的新聚合方法。 张将研究亲核N-杂环卡宾介导的N-取代-N-羧基酸酐开环聚合的动力学和机理。 将制备各种环状和线性嵌段共聚物，并研究它们在溶液中形成的聚集体的类型。 该教育计划的重点是将研究项目的概念融入路易斯安那州立大学的课程中，并改进路易斯安那州立大学 K-12 外展项目，包括 ChemDemo 和“You Be the Chemist”。 这项工作将扩大科学家可用来开发新聚合物和材料的生物相关聚合物的范围。 除了开发新方法之外，拟议的研究将使研究人员能够创造出可在生物成像和生物医学技术中应用的仿生聚合物。