Renovation and Modernization of the Center for Interdisciplinary Molecular Biology Education, Research and Advancement at California State University, Sacramento

加州州立大学萨克拉门托分校跨学科分子生物学教育、研究和进步中心的翻新和现代化

• 批准号: 0963261
• 负责人: Thomas Savage
• 金额: $ 75.5万
• 依托单位: University Enterprises, Incorporated
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0963261&HistoricalAwards=false
• 关键词: Renovation; Modernization; Center; Interdisciplinary; Molecular

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Center for Interdisciplinary Molecular Biology Education, Research and Advancement (CIMERA) is a research equipment facility shared among faculty from the departments of Biological Sciences and Chemistry at California State University, Sacramento. CIMERA is housed in an eight-room suite in the basement of Sequoia Hall originally built as an animal care facility. The original design of the suite limits its utility as a cell and molecular biology laboratory. Recent funding for additional cell analysis and cell culture equipment, and recent expansion of student/faculty research and research training activities, necessitates expanding and updating the facility. Funds are provided to allow the CIMERA facility to expand and modernize. The renovation involves (1) removing an incinerator, unusual floor and loft, autoclave and cage washer to generate additional space to allow expansion of the cell analysis and mammalian and bacterial cell culture laboratories, (2) updating the ceiling, lighting, flooring, electrical service and network connectivity to a standard appropriate for a modern molecular cell biology laboratory and (3) updating the benches, cabinetry and plumbing for use as a molecular cell biology laboratory. These renovations will create: a modern cell analysis laboratory, an expanded the mammalian cell culture laboratory, a large equipment room, a bacterial cell culture laboratory, and a modernization of the molecular biology laboratory. The facility provides basic cell culture, molecular biology and cell analysis equipment that support the research programs of 16 faculty, addressing fundamental problems such as the molecular events of vertebrate egg fertilization, the structure and function of apolipoprotein A-I, cellular differentiation during embryogenesis and fundamental techniques in forensic DNA analysis. In addition, the facility supports five different research training programs, several of which are targeted at underrepresented groups that provide undergraduate and Master's-level students with independent or semi-independent research experiences. These renovations will enhance the research programs of participating faculty and the training of their students, resulting in the ability to provide research experiences for approximately 20 additional students. This project will advance individual faculty research programs addressing fundamental problems in protein biochemistry, molecular and cell biology and forensic molecular biology. Furthermore, the renovation will enhance the research training of undergraduate and Master's level students by providing a modern molecular and cell biology equipment facility. It will increase the involvement of underrepresented groups in the sciences by providing specific research training experiences to students from underrepresented groups at Sacramento State and transferring from local community colleges.

该奖项由 2009 年美国复苏和再投资法案（公法 111-5）资助。跨学科分子生物学教育、研究和进步中心 (CIMERA) 是一个由生物科学系和生物科学系的教员共享的研究设备设施。加州州立大学萨克拉门托分校化学系。 CIMERA 位于 Sequoia Hall 地下室的一间八室套房内，该套房最初是作为动物护理设施建造的。该套件的原始设计限制了其作为细胞和分子生物学实验室的实用性。最近为额外的细胞分析和细胞培养设备提供的资金，以及最近学生/教师研究和研究培训活动的扩大，需要扩大和更新该设施。提供资金用于 CIMERA 设施的扩建和现代化。翻新工程包括 (1) 拆除焚烧炉、不寻常的地板和阁楼、高压灭菌器和笼式清洗机，以产生额外的空间，以便扩展细胞分析以及哺乳动物和细菌细胞培养实验室，(2) 更新天花板、照明、地板、电气设备服务和网络连接符合适合现代分子细胞生物学实验室的标准；(3) 更新用作分子细胞生物学实验室的工作台、橱柜和管道。这些改造将创建：一个现代化的细胞分析实验室、一个扩建的哺乳动物细胞培养实验室、一个大型设备室、一个细菌细胞培养实验室和一个现代化的分子生物学实验室。 该设施提供基础细胞培养、分子生物学和细胞分析设备，支持 16 名教师的研究项目，解决脊椎动物卵子受精的分子事件、载脂蛋白 A-I 的结构和功能、胚胎发生过程中的细胞分化和基本技术等基本问题。在法医 DNA 分析中。此外，该设施还支持五个不同的研究培训项目，其中一些项目针对代表性不足的群体，为本科生和硕士水平的学生提供独立或半独立的研究经验。这些改造将加强参与教师的研究项目和学生的培训，从而能够为大约 20 名额外的学生提供研究经验。该项目将推进个别教师的研究项目，解决蛋白质生物化学、分子和细胞生物学以及法医分子生物学的基本问题。此外，改造还将通过提供现代化的分子和细胞生物学设备设施来加强本科生和硕士生的研究训练。 它将通过为萨克拉门托州立大学代表性不足群体以及从当地社区学院转学的学生提供具体的研究培训经验，增加代表性不足群体对科学的参与。