Genome-Wide Diversity In Village Dogs: Unvcovering The History Of Dog Domestication, The Genetics Of Natural Dog Populations, & Consequences Of Artificial Selection In Breed D

乡村狗的全基因组多样性：揭示狗驯化的历史，自然狗种群的遗传学，

基本信息

批准号：
0948510
负责人：
Andrew Clark
金额：
$ 29.64万
依托单位：
Cornell Univ - State: AWDS MADE PRIOR MAY 2010
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-15 至 2011-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0948510&HistoricalAwards=false
关键词：
Genome Wide Diversity Village Dogs

项目摘要

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Dogs descended from Eurasian gray wolves, but where and how this process occurred is poorly understood. Much genetic research has focused on breed dogs, but the diverse populations of semi-feral "village" dogs are likely an important key for understanding dog domestication. In this project, samples will be collected and analyzed for village dogs across Eurasia and compared to samples from breed dogs and wolves. Genotyping will be done on high-throughput (60,000 marker) arrays yielding unprecedented resolution of the dog genome, but only a partial picture of genetic diversity since these markers consist largely of variants found from the boxer and poodle genomes. Therefore, sequencing a subset of village dogs and wolves will be done to detect novel variation in these groups and determine how much biased marker ascertainment affects genetic inference from these arrays.As high-throughput genomic tools are developed for more and more organisms, tremendous research opportunities exist for studying related populations and species. Developing methods of genetic inference robust to ascertainment bias is crucial for utilizing these tools. This study will likely to challenge current theories of dog origins and develop village dogs into a useful system for the study of domestication, speciation, behavior and morphology.

该奖项是根据2009年的《美国复苏与再投资法》（公法111-5）的资助。从欧亚灰狼降生的dogs，但对此过程的发生何处以及如何发生。许多遗传研究集中在繁殖犬上，但是半铁犬的不同种群可能是理解狗驯化的重要关键。在该项目中，将收集样品并分析欧亚大陆的乡村狗，并将其与犬和狼的样品进行比较。基因分型将在高通量（60,000个标记）阵列上进行，以产生狗基因组的前所未有的分辨率，但只有部分遗传多样性的图像，因为这些标记很大程度上是由Boxer和Poodle基因组发现的变体组成的。因此，将进行对乡村狗和狼的子集进行测序，以检测这些群体中的新变化，并确定有偏见的标记确定性影响了这些阵列的遗传学推断。作为越来越多的生物体开发了越来越多的生物体，存在巨大的研究机会，用于研究相关的种群和物种。开发遗传推理的方法鲁棒至确定性偏差对于利用这些工具至关重要。这项研究可能会挑战当前的狗起源理论，并将乡村狗发展成一个有用的系统，用于研究驯化，形成，行为和形态。