MRI: Acquisition of a tandem (IT-TOF) mass spectrometer system for biological research and application

MRI：购买串联（IT-TOF）质谱仪系统用于生物研究和应用

• 批准号: 0923027
• 负责人: Ka-yiu San
• 金额: --
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923027&HistoricalAwards=false
• 关键词: MRI; Acquisition; tandem; TOF; mass

0923027SanThe goal of this proposal is to establish a central mass spectrometry facility for biological research and education. To achieve this goal, a multidisciplinary research team has been assembled. Several of these team members share the same research interests and synergistic collaborations/interactions among the group already exist. The facility will support a wide range of research activities, spanning across five academic departments which include: Bioengineering, Chemical and Biomolecular Engineering, Civil and Environmental Engineering, Biochemistry and Cell Biology, and Chemistry. The facility will provide much needed quantitative and analytical instrumentation for a number of biological projects. They propose to equip the facility with an ion trap time of flight (2D-nano-LC-IT-TOF) mass spectrometer. In addition, the mass spectrometer will be interfaced with a 2-D nano-LC system to further enhance their analytical capability. The instrumentation requested in this proposal will provide the necessary quantitative and analytical tools for many projects at the interface of biology and chemistry or engineering. These projects will result in a better understanding of biological properties and functions, better design of biocatalysts for the synthesis of bioproducts, and better strategies for bioremediation. In addition, the facility will also serve as an effective vehicle to foster and strengthen multidisciplinary interactions and generate new ideas and collaborative projects. The projects will provide training opportunities for graduate and undergraduate students and postdoctoral research associates. Students participating in these types of research projects will benefit from highly interdisciplinary training in biochemical and metabolic engineering, biosystems engineering, biochemistry and molecular biology. In addition, new laboratory modules, which will be integrated into existing courses, will be developed. As in the past, the laboratories will continue to provide training opportunities for many women and minority graduate, undergraduate and high school students.

0923027San 该提案的目标是建立一个用于生物研究和教育的中央质谱设施。为了实现这一目标，我们组建了一个多学科研究团队。这些团队成员中的一些人具有相同的研究兴趣，并且团队之间已经存在协同合作/互动。该设施将支持广泛的研究活动，涵盖五个学术部门，包括：生物工程、化学和生物分子工程、土木和环境工程、生物化学和细胞生物学以及化学。该设施将为许多生物项目提供急需的定量和分析仪器。他们建议为该设施配备离子阱飞行时间 (2D-nano-LC-IT-TOF) 质谱仪。此外，质谱仪将与二维纳米LC系统连接，以进一步增强其分析能力。该提案中要求的仪器将为生物学和化学或工程学交叉领域的许多项目提供必要的定量和分析工具。这些项目将有助于更好地了解生物特性和功能，更好地设计用于生物产品合成的生物催化剂，以及更好的生物修复策略。此外，该设施还将作为促进和加强多学科互动并产生新想法和合作项目的有效工具。这些项目将为研究生、本科生以及博士后研究员提供培训机会。参与此类研究项目的学生将受益于生物化学和代谢工程、生物系统工程、生物化学和分子生物学的高度跨学科培训。此外，还将开发新的实验室模块，并将其整合到现有课程中。与过去一样，实验室将继续为许多女性和少数族裔研究生、本科生和高中生提供培训机会。